Featured Research

from universities, journals, and other organizations

Key Component In Mammalian Telomere Maintenance Found

Date:
November 20, 2000
Source:
Cold Spring Harbor Laboratory
Summary:
Research into telomere maintenance is at the forefront of the biomedical investigation of aging and cancer. Telomeres, the specialized ends of eukaryotic chromosomes, are required for normal cell growth. Recently, a collaboration of scientists from around the country has discovered a key component in the mammalian telomere maintenance machinery. As reported in Genes & Development, Hsu and colleagues have found that the protein Ku mediates mammalian telomere capping.

Research into telomere maintenance is at the forefront of the biomedical investigation of aging and cancer. Telomeres, the specialized ends of eukaryotic chromosomes, are required for normal cell growth. Recently, a collaboration of scientists from around the country has discovered a key component in the mammalian telomere maintenance machinery. As reported in Genes & Development, Hsu and colleagues have found that the protein Ku mediates mammalian telomere capping.

Related Articles


Telomere capping conceals and disguises the ends of chromosomal DNA so to distinguish it from double stranded DNA breaks. Telomere capping thereby prevents the fusion of chromosome ends, an event associated with genetic instability and a hallmark in the development of cancer. The association of Ku with the mammalian telomere was, though, a surprising discovery.

Ku was originally discovered as a member of the DNA damage repair complex which repairs double stranded DNA breaks. One would expect that such proteins would be excluded from the telomeres, but that is not the case. Hsu and colleagues determined that Ku acts in a unique way at the mammalian telomere. Ku specifically binds a telomere binding protein, and is required to prevent telomere end fusion. Mouse cells that lack Ku develop numerous chromosome fusions.

Ku works at the mammalian telomere in a functionally distinct manner from its action at double stranded breaks. Understanding the surprising association of Ku with the mammalian telomere is a primary step in understanding the delicate balance of cellular growth control and the aberrations which lead to cancer.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Key Component In Mammalian Telomere Maintenance Found." ScienceDaily. ScienceDaily, 20 November 2000. <www.sciencedaily.com/releases/2000/11/001120073646.htm>.
Cold Spring Harbor Laboratory. (2000, November 20). Key Component In Mammalian Telomere Maintenance Found. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2000/11/001120073646.htm
Cold Spring Harbor Laboratory. "Key Component In Mammalian Telomere Maintenance Found." ScienceDaily. www.sciencedaily.com/releases/2000/11/001120073646.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins