Featured Research

from universities, journals, and other organizations

Key Component In Mammalian Telomere Maintenance Found

Date:
November 20, 2000
Source:
Cold Spring Harbor Laboratory
Summary:
Research into telomere maintenance is at the forefront of the biomedical investigation of aging and cancer. Telomeres, the specialized ends of eukaryotic chromosomes, are required for normal cell growth. Recently, a collaboration of scientists from around the country has discovered a key component in the mammalian telomere maintenance machinery. As reported in Genes & Development, Hsu and colleagues have found that the protein Ku mediates mammalian telomere capping.

Research into telomere maintenance is at the forefront of the biomedical investigation of aging and cancer. Telomeres, the specialized ends of eukaryotic chromosomes, are required for normal cell growth. Recently, a collaboration of scientists from around the country has discovered a key component in the mammalian telomere maintenance machinery. As reported in Genes & Development, Hsu and colleagues have found that the protein Ku mediates mammalian telomere capping.

Related Articles


Telomere capping conceals and disguises the ends of chromosomal DNA so to distinguish it from double stranded DNA breaks. Telomere capping thereby prevents the fusion of chromosome ends, an event associated with genetic instability and a hallmark in the development of cancer. The association of Ku with the mammalian telomere was, though, a surprising discovery.

Ku was originally discovered as a member of the DNA damage repair complex which repairs double stranded DNA breaks. One would expect that such proteins would be excluded from the telomeres, but that is not the case. Hsu and colleagues determined that Ku acts in a unique way at the mammalian telomere. Ku specifically binds a telomere binding protein, and is required to prevent telomere end fusion. Mouse cells that lack Ku develop numerous chromosome fusions.

Ku works at the mammalian telomere in a functionally distinct manner from its action at double stranded breaks. Understanding the surprising association of Ku with the mammalian telomere is a primary step in understanding the delicate balance of cellular growth control and the aberrations which lead to cancer.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Key Component In Mammalian Telomere Maintenance Found." ScienceDaily. ScienceDaily, 20 November 2000. <www.sciencedaily.com/releases/2000/11/001120073646.htm>.
Cold Spring Harbor Laboratory. (2000, November 20). Key Component In Mammalian Telomere Maintenance Found. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2000/11/001120073646.htm
Cold Spring Harbor Laboratory. "Key Component In Mammalian Telomere Maintenance Found." ScienceDaily. www.sciencedaily.com/releases/2000/11/001120073646.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins