Featured Research

from universities, journals, and other organizations

Why Diet Drug Phen/Fen Damaged The Heart

Date:
December 15, 2000
Source:
Case Western Reserve University
Summary:
Three years ago, the diet drug phen/fen was pulled from the market for causing heart valve damage. Fenfluramine, also known as dexfenflurmamine, the "fen" part, was found to be the culprit. A new study published in the December 5 issue of the American Heart Association's journal Circulation explains some of the underlying mechanisms about why the diet drug damaged the heart.

CLEVELAND -- Three years ago, the diet drug phen/fen was pulled from the market for causing heart valve damage. Fenfluramine, also known as dexfenflurmamine, the "fen" part, was found to be the culprit.

Related Articles


A new study published in the December 5 issue of the American Heart Association's journal Circulation explains some of the underlying mechanisms about why the diet drug damaged the heart. Led by researchers from Case Western Reserve University's School of Medicine and the National Institute of Drug Abuse, the study screened fen, phentermine (phen), and several other drugs to see if they activated neurotransmitter receptors that can damage hearts.

Fen and two migraine drugs, ergotamine and methysergide, which also are known to cause heart valve damage, were found to activate the serotonin receptor known as 5-HT2B located on heart's valves (both the mitral and aortic). Serotonin is a neurotransmitter that affects a range of behaviors, including feeding, sleep and mood regulation.

According to Bryan L. Roth, associate professor of biochemistry, psychiatry and neurosciences at CWRU, and the paper's senior author, the findings suggest that activation of 5-HT2B receptors may be necessary to produce heart valve damage.

"The study points to a need for all potential medications to be screened to see if they engage the 5-HT2B receptor before passing approval. This is of great public health importance," Roth said.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "Why Diet Drug Phen/Fen Damaged The Heart." ScienceDaily. ScienceDaily, 15 December 2000. <www.sciencedaily.com/releases/2000/12/001214081821.htm>.
Case Western Reserve University. (2000, December 15). Why Diet Drug Phen/Fen Damaged The Heart. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2000/12/001214081821.htm
Case Western Reserve University. "Why Diet Drug Phen/Fen Damaged The Heart." ScienceDaily. www.sciencedaily.com/releases/2000/12/001214081821.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins