Featured Research

from universities, journals, and other organizations

Enzyme Could Provide Continual Fat Burning

Date:
April 2, 2001
Source:
Baylor College Of Medicine
Summary:
An enzyme discovered by Baylor College of Medicine researchers is critical to the metabolic pathway that governs the body's ability to burn fat and could open a door into new ways to reduce obesity, diabetes and other fat-related human diseases.

HOUSTON--(March 29, 2001) -- An enzyme discovered by Baylor College of Medicine researchers is critical to the metabolic pathway that governs the body's ability to burn fat and could open a door into new ways to reduce obesity, diabetes and other fat-related human diseases.

In an article in the March 30 issue of the journal Science, Dr. Salih Wakil described laboratory mice, whose genes were manipulated to make them deficient in the enzyme acetyl-CoA carboxylase 2, or ACC2, as being able to eat as much as 40 percent more than normal mice and weigh 10 to 15 percent less.

ACC1 and ACC2 are involved in producing malonyl-CoA, which is key to the formation of fatty acids and to fat burning. Wakil, chairman of Baylor's department of biochemistry and molecular biology, and his colleagues found that there are two pools of malonyl-CoA in the cell. The one in which ACC1 is important is critical to the formation of the long carbon chain component of fatty acids. The other pool associated with ACC2 regulates the transfer of fatty acids to the mitochondria, the cell's powerhouse. Without AAC2, fat burns continuously in the mitochondria.

ACC2 was identified in Wakil's laboratory in 1989 where researchers sequenced its DNA and located it on the chromosome. To determine the different effects of ACC1 and ACC2, Wakil and his colleagues created two forms of "knock-out" mice. The mice that lacked ACC1 died as embryos, demonstrating the value of fat in development.

"However, the mice genetically engineered to lack ACC2 seem very happy, live and breed well," Wakil said. The difference was that they ate more, weighed less and accumulated less fat than the normal animals.

Studies demonstrated that the ACC2-deficient mice had nearly one-half the fat of the normal mice. The fatty livers of normal mice looked pale compared to the bright red, virtually fat-free livers of the genetically engineered animals.

In one study, the researchers gave the ACC2-deficient mice insulin, which is produced in response to eating carbohydrates. In a normal system, insulin stimulates production of an enzyme that activates ACC1 and ACC2, increasing the production of fatty acids and inhibiting the burning of fat. However, in the ACC2-deficient mouse, "fat oxidation continues in the presence of insulin," Wakil said.

"This enzyme ACC2 could be a target for generating drugs that could regulate the burning of fat," Wakil said. "It could be important in the regulation of obesity, treatment of diabetes and eventually even the utilization and accumulation of fat, which could affect diseases such as atherosclerosis."

Co-authors were Drs. Lutfi Abu-Elheiga and K.A.H. Abo-Hashema in collaboration with Martin M. Matzuk.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Enzyme Could Provide Continual Fat Burning." ScienceDaily. ScienceDaily, 2 April 2001. <www.sciencedaily.com/releases/2001/03/010330071754.htm>.
Baylor College Of Medicine. (2001, April 2). Enzyme Could Provide Continual Fat Burning. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2001/03/010330071754.htm
Baylor College Of Medicine. "Enzyme Could Provide Continual Fat Burning." ScienceDaily. www.sciencedaily.com/releases/2001/03/010330071754.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins