Featured Research

from universities, journals, and other organizations

Enzyme Could Provide Continual Fat Burning

Date:
April 2, 2001
Source:
Baylor College Of Medicine
Summary:
An enzyme discovered by Baylor College of Medicine researchers is critical to the metabolic pathway that governs the body's ability to burn fat and could open a door into new ways to reduce obesity, diabetes and other fat-related human diseases.

HOUSTON--(March 29, 2001) -- An enzyme discovered by Baylor College of Medicine researchers is critical to the metabolic pathway that governs the body's ability to burn fat and could open a door into new ways to reduce obesity, diabetes and other fat-related human diseases.

In an article in the March 30 issue of the journal Science, Dr. Salih Wakil described laboratory mice, whose genes were manipulated to make them deficient in the enzyme acetyl-CoA carboxylase 2, or ACC2, as being able to eat as much as 40 percent more than normal mice and weigh 10 to 15 percent less.

ACC1 and ACC2 are involved in producing malonyl-CoA, which is key to the formation of fatty acids and to fat burning. Wakil, chairman of Baylor's department of biochemistry and molecular biology, and his colleagues found that there are two pools of malonyl-CoA in the cell. The one in which ACC1 is important is critical to the formation of the long carbon chain component of fatty acids. The other pool associated with ACC2 regulates the transfer of fatty acids to the mitochondria, the cell's powerhouse. Without AAC2, fat burns continuously in the mitochondria.

ACC2 was identified in Wakil's laboratory in 1989 where researchers sequenced its DNA and located it on the chromosome. To determine the different effects of ACC1 and ACC2, Wakil and his colleagues created two forms of "knock-out" mice. The mice that lacked ACC1 died as embryos, demonstrating the value of fat in development.

"However, the mice genetically engineered to lack ACC2 seem very happy, live and breed well," Wakil said. The difference was that they ate more, weighed less and accumulated less fat than the normal animals.

Studies demonstrated that the ACC2-deficient mice had nearly one-half the fat of the normal mice. The fatty livers of normal mice looked pale compared to the bright red, virtually fat-free livers of the genetically engineered animals.

In one study, the researchers gave the ACC2-deficient mice insulin, which is produced in response to eating carbohydrates. In a normal system, insulin stimulates production of an enzyme that activates ACC1 and ACC2, increasing the production of fatty acids and inhibiting the burning of fat. However, in the ACC2-deficient mouse, "fat oxidation continues in the presence of insulin," Wakil said.

"This enzyme ACC2 could be a target for generating drugs that could regulate the burning of fat," Wakil said. "It could be important in the regulation of obesity, treatment of diabetes and eventually even the utilization and accumulation of fat, which could affect diseases such as atherosclerosis."

Co-authors were Drs. Lutfi Abu-Elheiga and K.A.H. Abo-Hashema in collaboration with Martin M. Matzuk.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Enzyme Could Provide Continual Fat Burning." ScienceDaily. ScienceDaily, 2 April 2001. <www.sciencedaily.com/releases/2001/03/010330071754.htm>.
Baylor College Of Medicine. (2001, April 2). Enzyme Could Provide Continual Fat Burning. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2001/03/010330071754.htm
Baylor College Of Medicine. "Enzyme Could Provide Continual Fat Burning." ScienceDaily. www.sciencedaily.com/releases/2001/03/010330071754.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins