Featured Research

from universities, journals, and other organizations

Recently-Discovered Protein Could Be Key To Understanding And Preventing Type-2 Diabetes, Yale Researchers Find

Date:
June 6, 2001
Source:
Yale University
Summary:
A protein called Akt2 or Protein Kinase B plays an important role in maintaining glucose balance, possibly leading to a drug target for preventing Type-2 diabetes, Yale researchers report in a study published in the June 1 issue of Science.

New Haven, Conn. -- A protein called Akt2 or Protein Kinase B plays an important role in maintaining glucose balance, possibly leading to a drug target for preventing Type-2 diabetes, Yale researchers report in a study published in the June 1 issue of Science.

Related Articles


"When we inactivated the Akt2 protein in study mice, we found that these mice had defects in insulin's action in liver and skeletal muscle, suggesting that Akt2 plays an important role in insulin signaling and action," said Jason Kim, an author on the study and a research scientist in the Department of Internal Medicine at Yale School of Medicine.

"We also found that this defect in liver and skeletal muscle insulin action altered whole body glucose homeostasis, suggesting that Akt2 might have a role in the development of diabetes," Kim added.

Type 2 diabetes is the most common metabolic disease in the world, affecting 120 million people. Insulin resistance plays a primary role in the development of the disease. Kim said diabetes research is now focused on understanding how insulin acts in the body, especially in the area of the insulin signaling pathway. Insulin acts by binding to a receptor that activates a cascade of proteins that are both known and unknown, causing the cells to increase glucose use. The role of the Akt2 protein had been uncertain until co-authors at the University of Pennsylvania provided lab-generated mice with inactivation of the Akt2 protein.

"These mice develop diabetes in a pattern similar to human diabetes and future studies will examine whether a mutation in the Akt2 protein is also seen in people with diabetes," said Kim who is also an associate at the Howard Hughes Medical Institute and a co-director of NIH-Yale Mouse Metabolic Phenotyping Center. "A defect in this protein in humans can explain how diabetes develops."

Other authors on the study included Gerald I. Shulman, M.D. of Yale; Han Cho, Joanne L. Thorvaldsen, Qingwei Chu, E. Bryan Crenshaw III, Klaus H. Kaestner and Morris J. Birnbaum of the University of Pennsylvania; and Marisa S. Bartolomei of the Howard Hughes Medical Institute and the University of Pennsylvania.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Recently-Discovered Protein Could Be Key To Understanding And Preventing Type-2 Diabetes, Yale Researchers Find." ScienceDaily. ScienceDaily, 6 June 2001. <www.sciencedaily.com/releases/2001/06/010605073031.htm>.
Yale University. (2001, June 6). Recently-Discovered Protein Could Be Key To Understanding And Preventing Type-2 Diabetes, Yale Researchers Find. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2001/06/010605073031.htm
Yale University. "Recently-Discovered Protein Could Be Key To Understanding And Preventing Type-2 Diabetes, Yale Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2001/06/010605073031.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins