Featured Research

from universities, journals, and other organizations

Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose

Date:
September 13, 2001
Source:
American Heart Association
Summary:
Some individuals may have a clear advantage when it comes to keeping their bellies from sagging, according to researchers who have identified a genetic variation of a protein that may reduce the accumulation of body fat. The study appears in Circulation: Journal of the American Heart Association.

DALLAS, Sept. 11 – Some individuals may have a clear advantage when it comes to keeping their bellies from sagging, according to researchers who have identified a genetic variation of a protein that may reduce the accumulation of body fat. The study appears in today’s Circulation: Journal of the American Heart Association.

Related Articles


The protein, called apolipoprotein A-II (apo A-II) is a major component of high-density lipoprotein (HDL), sometimes referred to as “good cholesterol” due to its role in reverse cholesterol transport, the process by which cholesterol molecules are transported from the blood vessels and other tissues to the liver. If this process is defective, cholesterol molecules can accumulate in the arteries, helping to clog them and raising the risk of heart attack and stroke. There is evidence that increased levels of apo A-II can lead to slower removal of cholesterol and, ultimately, more build-up in the arteries.

“Animal studies have shown that apo A-II not only plays a role in reverse cholesterol transport, but is also important in other processes related to fat metabolism. However, until now, little has been known about its significance in human metabolism,” says lead researcher Ferdinand van ’t Hooft, M.D., Ph.D., of the Karolinska Institute, in Stockholm, Sweden. “This study provides the first evidence in humans for an extended role of apo A-II, in particular in relation to triglyceride and body fat accumulation.”

The researchers studied the effect of specific variations of the apo A-II gene in a group of 624 healthy, 50-year-old men. In these subjects, apo A-II concentration, levels of blood fats and quantity of body fat were related to a newly discovered, common genetic variation in the apo A-II gene called the 265T/C polymorphism.

They found that men with the 265C variant had lower apo A-II levels, decreased waist circumference and an enhanced metabolism of plasma triglycerides, compared to men with the 265T variant. Using cell culture systems, the researchers also demonstrated that the effect of the 265T/C polymorphism is probably related to its impact on the rate of production of apo A-II.

“This report underlines the multifunctional role of apo A-II, and indicates – among other things – that apo A-II influences waist size,” says van ’t Hooft. “More importantly, our study suggests that apo A-II can influence several different risk factors for coronary heart disease, indicating that this protein plays a critical role in the development of atherosclerotic disease.”

The discovery of the 265T/C polymorphism provides a novel genetic tool to test this hypothesis and to evaluate the proposed atherogenic properties of apo A-II in humans, he adds.

Co-authors are Giacomo Ruotolo, M.D., Ph.D.; Susanna Boquist, M.D., Ph.D.; Ulf de Faire, M.D., Ph.D.; Gφsta Eggertsen, M.D., Ph.D.; and Anders Hamsten, M.D., Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose." ScienceDaily. ScienceDaily, 13 September 2001. <www.sciencedaily.com/releases/2001/09/010911073040.htm>.
American Heart Association. (2001, September 13). Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2001/09/010911073040.htm
American Heart Association. "Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose." ScienceDaily. www.sciencedaily.com/releases/2001/09/010911073040.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) — The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins