Featured Research

from universities, journals, and other organizations

Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose

Date:
September 13, 2001
Source:
American Heart Association
Summary:
Some individuals may have a clear advantage when it comes to keeping their bellies from sagging, according to researchers who have identified a genetic variation of a protein that may reduce the accumulation of body fat. The study appears in Circulation: Journal of the American Heart Association.

DALLAS, Sept. 11 – Some individuals may have a clear advantage when it comes to keeping their bellies from sagging, according to researchers who have identified a genetic variation of a protein that may reduce the accumulation of body fat. The study appears in today’s Circulation: Journal of the American Heart Association.

The protein, called apolipoprotein A-II (apo A-II) is a major component of high-density lipoprotein (HDL), sometimes referred to as “good cholesterol” due to its role in reverse cholesterol transport, the process by which cholesterol molecules are transported from the blood vessels and other tissues to the liver. If this process is defective, cholesterol molecules can accumulate in the arteries, helping to clog them and raising the risk of heart attack and stroke. There is evidence that increased levels of apo A-II can lead to slower removal of cholesterol and, ultimately, more build-up in the arteries.

“Animal studies have shown that apo A-II not only plays a role in reverse cholesterol transport, but is also important in other processes related to fat metabolism. However, until now, little has been known about its significance in human metabolism,” says lead researcher Ferdinand van ’t Hooft, M.D., Ph.D., of the Karolinska Institute, in Stockholm, Sweden. “This study provides the first evidence in humans for an extended role of apo A-II, in particular in relation to triglyceride and body fat accumulation.”

The researchers studied the effect of specific variations of the apo A-II gene in a group of 624 healthy, 50-year-old men. In these subjects, apo A-II concentration, levels of blood fats and quantity of body fat were related to a newly discovered, common genetic variation in the apo A-II gene called the 265T/C polymorphism.

They found that men with the 265C variant had lower apo A-II levels, decreased waist circumference and an enhanced metabolism of plasma triglycerides, compared to men with the 265T variant. Using cell culture systems, the researchers also demonstrated that the effect of the 265T/C polymorphism is probably related to its impact on the rate of production of apo A-II.

“This report underlines the multifunctional role of apo A-II, and indicates – among other things – that apo A-II influences waist size,” says van ’t Hooft. “More importantly, our study suggests that apo A-II can influence several different risk factors for coronary heart disease, indicating that this protein plays a critical role in the development of atherosclerotic disease.”

The discovery of the 265T/C polymorphism provides a novel genetic tool to test this hypothesis and to evaluate the proposed atherogenic properties of apo A-II in humans, he adds.

Co-authors are Giacomo Ruotolo, M.D., Ph.D.; Susanna Boquist, M.D., Ph.D.; Ulf de Faire, M.D., Ph.D.; Gφsta Eggertsen, M.D., Ph.D.; and Anders Hamsten, M.D., Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose." ScienceDaily. ScienceDaily, 13 September 2001. <www.sciencedaily.com/releases/2001/09/010911073040.htm>.
American Heart Association. (2001, September 13). Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2001/09/010911073040.htm
American Heart Association. "Gene Variant For Protein In "Good" Cholesterol Keeps Jeans Loose." ScienceDaily. www.sciencedaily.com/releases/2001/09/010911073040.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins