Featured Research

from universities, journals, and other organizations

Leptin Levels Linked To Heart Attack Risk

Date:
December 19, 2001
Source:
American Heart Association
Summary:
Leptin, a protein secreted by fat cells, may be an independent risk factor for heart disease in humans, according to an article in Circulation: Journal of the American Heart Association.

Leptin, a protein secreted by fat cells, may be an independent risk factor for heart disease in humans, according to an article today in Circulation: Journal of the American Heart Association. Leptin has been the subject of intense scrutiny since the early 1990s following its discovery. The protein, when given to mice who were genetically predisposed to obesity, caused weight loss by regulating appetite. However, early hopes that leptin could do the same for overweight humans have been dashed, says study author Naveed Sattar, M.D., Ph.D. Overweight and obese people seem to have some sort of resistance to leptin, he explains.

“This is the first evidence that leptin may be an independent risk factor for the development of coronary heart disease,” says Sattar, senior lecturer in endocrinology and metabolism and an honorary consultant in clinical biochemistry at Glasgow Royal Infirmary in Scotland. “Leptin appears to be as strong a predictor as some well-recognized risk factors such as high systolic blood pressure or low levels of high-density lipoprotein (HDL) cholesterol.”

He cautions that these results must be confirmed by other studies before recommending routine leptin testing.

“Leptin is such a brilliant blood marker for body fat for people at any weight and it is not difficult to measure,” he says.

Sattar’s study used frozen blood samples from the 1989 landmark West of Scotland Coronary Prevention Study (WOSCOPS), a prospective trial that showed that pravastatin, a cholesterol-lowering statin drug, could prevent coronary disease in people with no previous history of it. The current research compared 377 men from the original study who had heart attacks or procedures to open clogged arteries during five years of follow-up and 783 controls who remained free of heart disease events. The controls were matched to cases on the basis of age and smoking history.

The researchers found that leptin levels in the men with heart disease were 16 percent higher than in controls. When they looked at risk of cardiovascular events, Sattar’s team found a 25 percent increased risk for every 30 percent rise in leptin levels, an amount identified in the article as one standard deviation.

The researchers report that leptin remained a risk factor independent of body mass index (BMI), a commonly used way to determine if someone is overweight (BMI of 25 or higher) or obese (BMI of 30 or greater). In addition, leptin levels increased along with levels of C-reactive protein (CRP) – a marker for inflammation in the body that is strongly associated with the development of heart disease. However, when the two proteins were studied together, leptin was still a significant marker for heart disease.

Regarding the BMI findings, he explains that leptin is a better indication of fat mass, since people can have the same body mass index but have different amounts of fat in their bodies. The finding that leptin, a fat protein, is linked to heart disease risk independently from CRP, an inflammation marker, strongly suggests that fat may be important in heart disease risk, says Sattar.

“Leptin may give important information about the development of heart and blood vessel disease,” he says. “Perhaps because it is a good indicator of the amount of body fat a person has or an independent correlate of insulin resistance, since both leptin and CRP levels increase along with that condition.” Insulin resistance is a condition in which the body makes adequate amounts of insulin but the cells are resistant to using it efficiently.

“Our findings could also point toward some new way in which fat tissue promotes cardiovascular disease,” he says. Sattar notes that regular exercise can have immediate effects on leptin levels because it reduces the body’s fat content, even in the absence of weight loss.

Co-authors include: A. Michael Wallace, Ph.D.; Alex D. McMahon, Ph.D.; Chris J. Packard, D.Sc.; Anne Kelly, MIBiol; James Shepherd, Ph.D.; and Allan Gaw, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Leptin Levels Linked To Heart Attack Risk." ScienceDaily. ScienceDaily, 19 December 2001. <www.sciencedaily.com/releases/2001/12/011218073532.htm>.
American Heart Association. (2001, December 19). Leptin Levels Linked To Heart Attack Risk. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2001/12/011218073532.htm
American Heart Association. "Leptin Levels Linked To Heart Attack Risk." ScienceDaily. www.sciencedaily.com/releases/2001/12/011218073532.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins