Featured Research

from universities, journals, and other organizations

Study Finds Acute Measles Supresses HIV Replication

Date:
April 17, 2002
Source:
Johns Hopkins University Bloomberg School Of Public Health
Summary:
Replication of human immunodeficiency virus (HIV) is briefly suppressed during acute measles, according to researchers at the Johns Hopkins Bloomberg School of Public Health. A study of HIV-infected children living in Zambia found that HIV levels in the blood were significantly lower while having measles compared to HIV-infected children who did not have measles.

Replication of human immunodeficiency virus (HIV) is briefly suppressed during acute measles, according to researchers at the Johns Hopkins Bloomberg School of Public Health. A study of HIV-infected children living in Zambia found that HIV levels in the blood were significantly lower while having measles compared to HIV-infected children who did not have measles. The researchers say the only other illness previously reported to suppress HIV is O. tsutsugamushi, which causes scrub typhus. The study appears in the April 15, 2002 issue of The Journal of Infectious Diseases.

“We were surprised by these findings, because we expected to see HIV replication increase, not decrease with measles,” says the study’s lead author William Moss, MD, MPH, assistant research professor of international health and molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health. “Measles is a very immunosuppressive virus. It results in many secondary infections and is a major cause of death among children. Our findings show that measles also triggers intense immune system activation that temporarily suppresses HIV,” explains Dr. Moss.

For the study, Dr. Moss and his colleagues followed 93 children diagnosed with measles and HIV at the University Teaching Hospital in Lusaka, Zambia. The children’s HIV levels were measured from blood samples taken when they were admitted to the hospital for measles treatment. More samples were taken when the children were discharged from the hospital, and again one month later. They were compared with samples taken from HIV-infected children who did not have measles or other illnesses and with samples from children with measles, but not HIV.

The study found that 33 of the children diagnosed with measles and HIV had a median HIV level of 5,339 copies per milliliter when they first entered the hospital for treatment. The HIV levels increased to 60,121 copies per milliliter when measured at the time of discharge and to 387,148 copies per milliliter one month later. HIV-infected children who did not have acute measles had a median HIV level of 228,454 copies per milliliter.

The researchers also noticed that the CD8 T-cell level, which is an indicator of immune system response, was elevated in the children with both measles and HIV compared to children in the control groups. The increase in the CD8 level occurred during the same time as the suppression of HIV levels.

“More research will be needed with a larger study group to fully understand how measles suppresses HIV and activates the immune system, but our findings may provide clues to understanding both HIV pathogenesis and immunity,” says Diane Griffin, MD, PhD, professor and chair of the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.

“Suppression of Human Immunodeficiency Virus Replication during Acute Measles,” is published in the April 15, 2002 edition of The Journal of Infectious Diseases and was written by William J. Moss, Judith J. Ryon, Mwaka Monze, Felicity Cutts, Thomas C. Quinn, and Diane E. Griffin.

Funding was provided by the National Institutes of Health, World Health Organization, and from the Wyeth-Lederle Vaccines and Pediatrics Young Investigators Award in Vaccine Development of the Infectious Diseases Society of America.


Story Source:

The above story is based on materials provided by Johns Hopkins University Bloomberg School Of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins University Bloomberg School Of Public Health. "Study Finds Acute Measles Supresses HIV Replication." ScienceDaily. ScienceDaily, 17 April 2002. <www.sciencedaily.com/releases/2002/04/020417070226.htm>.
Johns Hopkins University Bloomberg School Of Public Health. (2002, April 17). Study Finds Acute Measles Supresses HIV Replication. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2002/04/020417070226.htm
Johns Hopkins University Bloomberg School Of Public Health. "Study Finds Acute Measles Supresses HIV Replication." ScienceDaily. www.sciencedaily.com/releases/2002/04/020417070226.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins