Featured Research

from universities, journals, and other organizations

Study Finds Acute Measles Supresses HIV Replication

Date:
April 17, 2002
Source:
Johns Hopkins University Bloomberg School Of Public Health
Summary:
Replication of human immunodeficiency virus (HIV) is briefly suppressed during acute measles, according to researchers at the Johns Hopkins Bloomberg School of Public Health. A study of HIV-infected children living in Zambia found that HIV levels in the blood were significantly lower while having measles compared to HIV-infected children who did not have measles.

Replication of human immunodeficiency virus (HIV) is briefly suppressed during acute measles, according to researchers at the Johns Hopkins Bloomberg School of Public Health. A study of HIV-infected children living in Zambia found that HIV levels in the blood were significantly lower while having measles compared to HIV-infected children who did not have measles. The researchers say the only other illness previously reported to suppress HIV is O. tsutsugamushi, which causes scrub typhus. The study appears in the April 15, 2002 issue of The Journal of Infectious Diseases.

“We were surprised by these findings, because we expected to see HIV replication increase, not decrease with measles,” says the study’s lead author William Moss, MD, MPH, assistant research professor of international health and molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health. “Measles is a very immunosuppressive virus. It results in many secondary infections and is a major cause of death among children. Our findings show that measles also triggers intense immune system activation that temporarily suppresses HIV,” explains Dr. Moss.

For the study, Dr. Moss and his colleagues followed 93 children diagnosed with measles and HIV at the University Teaching Hospital in Lusaka, Zambia. The children’s HIV levels were measured from blood samples taken when they were admitted to the hospital for measles treatment. More samples were taken when the children were discharged from the hospital, and again one month later. They were compared with samples taken from HIV-infected children who did not have measles or other illnesses and with samples from children with measles, but not HIV.

The study found that 33 of the children diagnosed with measles and HIV had a median HIV level of 5,339 copies per milliliter when they first entered the hospital for treatment. The HIV levels increased to 60,121 copies per milliliter when measured at the time of discharge and to 387,148 copies per milliliter one month later. HIV-infected children who did not have acute measles had a median HIV level of 228,454 copies per milliliter.

The researchers also noticed that the CD8 T-cell level, which is an indicator of immune system response, was elevated in the children with both measles and HIV compared to children in the control groups. The increase in the CD8 level occurred during the same time as the suppression of HIV levels.

“More research will be needed with a larger study group to fully understand how measles suppresses HIV and activates the immune system, but our findings may provide clues to understanding both HIV pathogenesis and immunity,” says Diane Griffin, MD, PhD, professor and chair of the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.

“Suppression of Human Immunodeficiency Virus Replication during Acute Measles,” is published in the April 15, 2002 edition of The Journal of Infectious Diseases and was written by William J. Moss, Judith J. Ryon, Mwaka Monze, Felicity Cutts, Thomas C. Quinn, and Diane E. Griffin.

Funding was provided by the National Institutes of Health, World Health Organization, and from the Wyeth-Lederle Vaccines and Pediatrics Young Investigators Award in Vaccine Development of the Infectious Diseases Society of America.


Story Source:

The above story is based on materials provided by Johns Hopkins University Bloomberg School Of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins University Bloomberg School Of Public Health. "Study Finds Acute Measles Supresses HIV Replication." ScienceDaily. ScienceDaily, 17 April 2002. <www.sciencedaily.com/releases/2002/04/020417070226.htm>.
Johns Hopkins University Bloomberg School Of Public Health. (2002, April 17). Study Finds Acute Measles Supresses HIV Replication. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2002/04/020417070226.htm
Johns Hopkins University Bloomberg School Of Public Health. "Study Finds Acute Measles Supresses HIV Replication." ScienceDaily. www.sciencedaily.com/releases/2002/04/020417070226.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins