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Natural Insecticide Identified As Potential Cancer Prevention Agent For Early Stage Lung Cancer

Date:
October 17, 2002
Source:
American Association For Cancer Research
Summary:
The use of deguelin, a natural plant extract most commonly used as an insecticide in Africa and South American, inhibits the growth of precancerous and cancerous lung cells, with no toxic effects on normal cells, according to a study presented at the first annual Frontiers in Cancer Prevention Research meeting convened by the American Association for Cancer Research. The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in non-small cell lung cancer (NSCLC), where constant activation of Akt occurs. Akt, or protein kinase B, is recognized as one of the most important molecules that promotes the survival of tumor cells by playing the critical role of controlling the balance between survival and apoptosis (programmed cell death).

Boston, MA (October 16, 2002) – The use of deguelin, a natural plant extract most commonly used as an insecticide in Africa and South American, inhibits the growth of precancerous and cancerous lung cells, with no toxic effects on normal cells, according to a study presented today at the first annual Frontiers in Cancer Prevention Research meeting convened by the American Association for Cancer Research. The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in non-small cell lung cancer (NSCLC), where constant activation of Akt occurs. Akt, or protein kinase B, is recognized as one of the most important molecules that promotes the survival of tumor cells by playing the critical role of controlling the balance between survival and apoptosis (programmed cell death).


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The above story is based on materials provided by American Association For Cancer Research. Note: Materials may be edited for content and length.


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American Association For Cancer Research. "Natural Insecticide Identified As Potential Cancer Prevention Agent For Early Stage Lung Cancer." ScienceDaily. ScienceDaily, 17 October 2002. <www.sciencedaily.com/releases/2002/10/021017065709.htm>.
American Association For Cancer Research. (2002, October 17). Natural Insecticide Identified As Potential Cancer Prevention Agent For Early Stage Lung Cancer. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2002/10/021017065709.htm
American Association For Cancer Research. "Natural Insecticide Identified As Potential Cancer Prevention Agent For Early Stage Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2002/10/021017065709.htm (accessed April 20, 2014).

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