Featured Research

from universities, journals, and other organizations

ACE Linked To Calcium Growth On Aortic Valve

Date:
October 23, 2002
Source:
University Of Washington
Summary:
Future studies may find that ACE inhibitors, a class of drugs now taken by people with high blood pressure, could slow down or prevent the development of aortic valve calcium, say University of Washington researchers. Currently, the only treatment for severe calcium in the aortic valve is surgical replacement.

Future studies may find that ACE inhibitors, a class of drugs now taken by people with high blood pressure, could slow down or prevent the development of aortic valve calcium, say University of Washington researchers. Currently, the only treatment for severe calcium in the aortic valve is surgical replacement.

Related Articles


"Since we already know that ACE inhibition has benefit in a similar disease, atherosclerosis, further study of this therapy in calcific aortic valvular disease makes a lot of sense," says the lead author, Dr. Kevin O’Brien, an associate professor of medicine in the UW School of Medicine’s Division of Cardiology.

In the study, published in the Oct. 22 issue of Circulation, O’Brien and colleagues analyzed 21 human aortic valves, either from autopsy or from people who were having their valves replaced. Angiotensin-converting enzyme, or ACE, was not detected in normal aortic valves, but was present in all valves with lesions.

ACE was found in association with LDL cholesterol, both in lesions and in the bloodstream, raising the possibility that LDL carries the ACE into lesions, where the ACE then contributes to aortic valve disease development. The findings also raise the possibility that the association of ACE with LDL particles may be relevant to a number of diseases in which LDL accumulates, such as atherosclerosis and some renal diseases.

In March, O’Brien and colleagues published an article demonstrating that use of statins, which lower LDL levels, is associated with a lower rate of aortic valve calcification. According to O’Brien, "The new findings raise the possibility that ACE inhibitors also might be of benefit in patients with this disease."

However, O’Brien cautions that much more study is needed before ACE inhibitors are used routinely in patients with aortic valve disease.

The study was funded, in part, by King Pharmaceuticals, which manufactures an ACE inhibitor.

Other authors of the paper include Drs. Jeffrey L. Probstfield, David M. Shavelle, Michael T. Caulfield, Catherine M. Otto, and Thomas O. McDonald, M.S., all of the Division of Cardiology at UW, and Dr. Katherine Olin-Lewis of the Division of Metabolism, Endocrinology and Nutrition. Shavelle is currently at Harbor-UCLA Medical Center in Torrance, Calif, and Caulfield is currently at Massachusetts General Hospital Boston.


Story Source:

The above story is based on materials provided by University Of Washington. Note: Materials may be edited for content and length.


Cite This Page:

University Of Washington. "ACE Linked To Calcium Growth On Aortic Valve." ScienceDaily. ScienceDaily, 23 October 2002. <www.sciencedaily.com/releases/2002/10/021023065213.htm>.
University Of Washington. (2002, October 23). ACE Linked To Calcium Growth On Aortic Valve. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2002/10/021023065213.htm
University Of Washington. "ACE Linked To Calcium Growth On Aortic Valve." ScienceDaily. www.sciencedaily.com/releases/2002/10/021023065213.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins