Featured Research

from universities, journals, and other organizations

ACE Linked To Calcium Growth On Aortic Valve

Date:
October 23, 2002
Source:
University Of Washington
Summary:
Future studies may find that ACE inhibitors, a class of drugs now taken by people with high blood pressure, could slow down or prevent the development of aortic valve calcium, say University of Washington researchers. Currently, the only treatment for severe calcium in the aortic valve is surgical replacement.

Future studies may find that ACE inhibitors, a class of drugs now taken by people with high blood pressure, could slow down or prevent the development of aortic valve calcium, say University of Washington researchers. Currently, the only treatment for severe calcium in the aortic valve is surgical replacement.

Related Articles


"Since we already know that ACE inhibition has benefit in a similar disease, atherosclerosis, further study of this therapy in calcific aortic valvular disease makes a lot of sense," says the lead author, Dr. Kevin O’Brien, an associate professor of medicine in the UW School of Medicine’s Division of Cardiology.

In the study, published in the Oct. 22 issue of Circulation, O’Brien and colleagues analyzed 21 human aortic valves, either from autopsy or from people who were having their valves replaced. Angiotensin-converting enzyme, or ACE, was not detected in normal aortic valves, but was present in all valves with lesions.

ACE was found in association with LDL cholesterol, both in lesions and in the bloodstream, raising the possibility that LDL carries the ACE into lesions, where the ACE then contributes to aortic valve disease development. The findings also raise the possibility that the association of ACE with LDL particles may be relevant to a number of diseases in which LDL accumulates, such as atherosclerosis and some renal diseases.

In March, O’Brien and colleagues published an article demonstrating that use of statins, which lower LDL levels, is associated with a lower rate of aortic valve calcification. According to O’Brien, "The new findings raise the possibility that ACE inhibitors also might be of benefit in patients with this disease."

However, O’Brien cautions that much more study is needed before ACE inhibitors are used routinely in patients with aortic valve disease.

The study was funded, in part, by King Pharmaceuticals, which manufactures an ACE inhibitor.

Other authors of the paper include Drs. Jeffrey L. Probstfield, David M. Shavelle, Michael T. Caulfield, Catherine M. Otto, and Thomas O. McDonald, M.S., all of the Division of Cardiology at UW, and Dr. Katherine Olin-Lewis of the Division of Metabolism, Endocrinology and Nutrition. Shavelle is currently at Harbor-UCLA Medical Center in Torrance, Calif, and Caulfield is currently at Massachusetts General Hospital Boston.


Story Source:

The above story is based on materials provided by University Of Washington. Note: Materials may be edited for content and length.


Cite This Page:

University Of Washington. "ACE Linked To Calcium Growth On Aortic Valve." ScienceDaily. ScienceDaily, 23 October 2002. <www.sciencedaily.com/releases/2002/10/021023065213.htm>.
University Of Washington. (2002, October 23). ACE Linked To Calcium Growth On Aortic Valve. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2002/10/021023065213.htm
University Of Washington. "ACE Linked To Calcium Growth On Aortic Valve." ScienceDaily. www.sciencedaily.com/releases/2002/10/021023065213.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins