Featured Research

from universities, journals, and other organizations

Hopkins Study Finds Combined PET-CT Better At Detecting Ovarian Cancer

Date:
December 6, 2002
Source:
Johns Hopkins Medical Institutions
Summary:
Hopkins radiologists have found that a combination of positron emission tomography (PET) and computed tomography (CT) detects cancer spread better than PET alone. In a study to be presented at the Radiological Society of North America, researchers reported that overall, PET-CT improves the ability to distinguish cancerous from normal tissue and locate metastases, where they have spread. The study used a scanner that fuses CT technology, which provides anatomical detail, with PET images, which detects metabolic activity of tumors.

Hopkins radiologists have found that a combination of positron emission tomography (PET) and computed tomography (CT) detects cancer spread better than PET alone. In a study to be presented at the Radiological Society of North America, researchers reported that overall, PET-CT improves the ability to distinguish cancerous from normal tissue and locate metastases, where they have spread. The study used a scanner that fuses CT technology, which provides anatomical detail, with PET images, which detects metabolic activity of tumors.

Related Articles


Ten PET and 33 PET-CT scans were performed on 28 patients with ovarian cancer suspected to have spread to the abdominal cavity. There were three true positive and two true negative results with PET alone and 14 true positives and 10 true negatives with PET-CT. The PET scan alone produced two false positives, while PET-CT produced none. There were no false negatives with PET alone, and PET-CT had five. Combined PET-CT had a fairly high sensitivity rate, accurately diagnosing cancer 73.6 percent of the time (14 of 19), and PET alone was able to diagnose all three positive cancers.

"PET-CT was very specific, as it was able to distinguish cancer from non-cancer 100 percent of the time (10 of 10), while PET alone was specific for cancer only 50 percent of the time (two of four)," says Richard L. Wahl, M.D., the Henry N. Wagner Jr. professor of nuclear medicine and director of the division of nuclear medicine at Johns Hopkins. Routine contrast-enhanced CT was able to find disease in three of the five false negatives produced by PET-CT.

"The CT portion of combined PET-CT scanners is very helpful at locating disease, but it could miss some lesions that can be found with contrast-enhanced CT," says Elliot K. Fishman, M.D., professor of radiology and oncology and director of diagnostic imaging and body CT for the Kimmel Cancer Center at Johns Hopkins.

The researchers caution that this study is in a limited number of patients and additional research is necessary to determine the value of combined PET/CT over PET alone and over CT. "Nonetheless, our results are very promising and PET/CT is being used more often for patients with suspected recurrent ovarian cancer," says Wahl.

A second study by Wahl and Fishman being presented at the meeting (Abstract #740) shows how whole body CT provides a 19 percent improvement to combined PET-CT in detecting colorectal cancer recurrence.

Johns Hopkins was the first U.S. hospital to install a commercial combination PET-CT scanner for use with patients in a clinical setting. In addition to ovarian and colon cancer, the scanner is being used to detect a variety of cancers including breast, melanoma, and lung cancer.

In addition to Wahl and Fishman, other participants in this research were first author, Harpreet Pannu, M.D., Christian Cohade, M.D., Robert Bristow, M.D., and Fredrick Montz, M.D.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Hopkins Study Finds Combined PET-CT Better At Detecting Ovarian Cancer." ScienceDaily. ScienceDaily, 6 December 2002. <www.sciencedaily.com/releases/2002/12/021206075349.htm>.
Johns Hopkins Medical Institutions. (2002, December 6). Hopkins Study Finds Combined PET-CT Better At Detecting Ovarian Cancer. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2002/12/021206075349.htm
Johns Hopkins Medical Institutions. "Hopkins Study Finds Combined PET-CT Better At Detecting Ovarian Cancer." ScienceDaily. www.sciencedaily.com/releases/2002/12/021206075349.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins