Featured Research

from universities, journals, and other organizations

Contact Lenses That Dispense Prescription Drugs

Date:
March 24, 2003
Source:
American Chemical Society
Summary:
Eye diseases like glaucoma could one day be treated by pharmaceuticals delivered through contact lenses. Chemical engineers from the University of Florida say they've been able to make soft contact lenses containing tiny embedded particles that slowly release drugs directly where they're needed.

NEW ORLEANS, March 23 — Eye diseases like glaucoma could one day be treated by pharmaceuticals delivered through contact lenses. Chemical engineers from the University of Florida say they've been able to make soft contact lenses containing tiny embedded particles that slowly release drugs directly where they're needed.

Related Articles


The research was presented today at the 225th national meeting of the American Chemical Society, the world's largest scientific society, held this week in New Orleans.

"One of the biggest problems with using eye drops to deliver medication to the eyes is that about 95 percent of the medication goes where it's not needed," said Anuj Chauhan, Ph.D., one of the authors of the study.

He said that eye drops applied topically mix with tears, which then drain into the nasal cavity and from there, get into the bloodstream and to other organs, where the drugs can cause serious side effects. For example, Timolol, used to treat glaucoma, can cause heart problems. But drugs contained in a contact lens could be released slowly enough to stay in the eye.

Chauhan and his graduate student and coauthor, Derya Gulsen, have found a way to encapsulate a drug in nanoparticles — tiny particles much smaller than the eye can see — which can then be mixed into the contact lens matrix during manufacturing of the lens.

In theory, the disposable, drug-laden contact lenses could be worn for up to two weeks, steadily delivering a supply of the drug directly to the eye where it's needed. Rather than being exposed to a sudden high dose of medication — from an eye drop, for example — the patient gets the right amount of medicine all the time.

The same lenses could be used to correct vision while delivering medication. And for a person whose vision doesn't need to be corrected, the lenses could be made without correction.

Chauhan said the process could also be used to incorporate antibiotics into the matrix of a lens, making an extended-wear lens that would leave its wearer less vulnerable to bacterial infections — a chief drawback of such lenses today.

Other researchers have tried getting drugs into contact lenses, either by soaking the lenses in a drug solution or trapping the drug in a hollow cavity between two pieces of lens material. "But contact lenses soaked in drug solutions are not very effective at delivering medications for extended periods of time," Chauhan said. "Our approach allows us great flexibility in designing controlled drug delivery vehicles that can be tailored to different drugs, but are also effective for extended periods of time."

The lenses are in the very early engineering design stages and have not been tested clinically. "We're in the very preliminary stages of developing this technology right now," Chauhan says. No in vitro or animal testing has yet been done.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Contact Lenses That Dispense Prescription Drugs." ScienceDaily. ScienceDaily, 24 March 2003. <www.sciencedaily.com/releases/2003/03/030324063956.htm>.
American Chemical Society. (2003, March 24). Contact Lenses That Dispense Prescription Drugs. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2003/03/030324063956.htm
American Chemical Society. "Contact Lenses That Dispense Prescription Drugs." ScienceDaily. www.sciencedaily.com/releases/2003/03/030324063956.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins