Featured Research

from universities, journals, and other organizations

Researchers Discover New Class Of Human Stem Cells; Cells Show Promise For Cancer And Transplant Patients Because Of Rapid Growth In Bone Marrow

Date:
June 9, 2003
Source:
University Of Toronto
Summary:
Scientists with University Health Network have discovered a new class of human stem cells that rapidly grow when implanted in the bone marrow of mice. The findings, available today in an advance on-line publication of the international scientific journal Nature Medicine, are a major advancement in human stem cell research with possible significant clinical implications for designing more effective cancer therapies.

Toronto (June 9, 2003) – Scientists with University Health Network have discovered a new class of human stem cells that rapidly grow when implanted in the bone marrow of mice. The findings, available today in an advance on-line publication of the international scientific journal Nature Medicine, are a major advancement in human stem cell research with possible significant clinical implications for designing more effective cancer therapies.

“This is an exciting discovery because for the first time we have found human stem cells that rapidly rebuild a blood system,” said Dr. John Dick, lead author of the study, senior scientist with UHN, and a professor in the University of Toronto’s Department of Molecular and Medical Genetics. “The potential is that it may allow transplant patients to quickly regain their blood cells, which are critical to their immune system.”

The scientists identified the new stem cells after injecting a batch of stem cells directly into the bone of mice, instead of the traditional method of intravenous injection into the blood stream. They observed this new subpopulation of stem cells rapidly repopulate the blood-producing system of the mice, produced high levels of blood cells within the first week or two after transplant, which is one- to two-weeks earlier than the normal rate. This discovery builds on the Dr. Dick’s pioneering method of studying human stem cells by transplanting them into immunodeficient mice which will not reject the human cells.

The discovery could have far reaching implications for cancer and transplant patients whose immune systems are weakened by their treatment. These patients are very vulnerable to infections, usually for as long as three weeks after the treatment, until their blood system recovers enough to fight off infections.

“If these new human stem cells rebuild the blood system of a person as they have in the mice in this study, it may significantly reduce the time a patient is at risk,” said Dr. Armand Keating, Chief of Medical Oncology at Princess Margaret Hospital.

Further study is needed to see if the new stem cells can be separated in larger batches and to refine the method of delivery. “Implanting stem cells directly into bone is a more complex and difficult procedure than the traditional intravenous method,” said Dr. Dick.

###The research was supported by grants from the Association pour la Recherche contre le Cancer, the Stem Cell Network, one of Canada’s Networks of Centres of Excellence, the Canadian Cancer Society, the Canadian Genetic Diseases Network, and the Canadian Institutes of Health Research.

University Health Network is a major landmark in Canada’s healthcare system, and a teaching hospital of the University of Toronto. Building on the strengths and reputation of each of our three hospitals, Toronto General Hospital, Toronto Western Hospital and Princess Margaret Hospital, UHN brings together the talent and resources needed to achieve global impact and provide exemplary patient care, research and education.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Researchers Discover New Class Of Human Stem Cells; Cells Show Promise For Cancer And Transplant Patients Because Of Rapid Growth In Bone Marrow." ScienceDaily. ScienceDaily, 9 June 2003. <www.sciencedaily.com/releases/2003/06/030609010720.htm>.
University Of Toronto. (2003, June 9). Researchers Discover New Class Of Human Stem Cells; Cells Show Promise For Cancer And Transplant Patients Because Of Rapid Growth In Bone Marrow. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2003/06/030609010720.htm
University Of Toronto. "Researchers Discover New Class Of Human Stem Cells; Cells Show Promise For Cancer And Transplant Patients Because Of Rapid Growth In Bone Marrow." ScienceDaily. www.sciencedaily.com/releases/2003/06/030609010720.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins