Featured Research

from universities, journals, and other organizations

Inflammation Blocks Impact Of Heart Healthy Diets For Some

Date:
July 24, 2003
Source:
Johns Hopkins Medical Institutions
Summary:
Results of a Johns Hopkins study suggest that natural chemicals released in the body as a result of chronic inflammation may underpin the failure of low-fat, so-called heart healthy diets to actually reduce cholesterol and heart disease risk in some people.

Results of a Johns Hopkins study suggest that natural chemicals released in the body as a result of chronic inflammation may underpin the failure of low-fat, so-called heart healthy diets to actually reduce cholesterol and heart disease risk in some people.

According to the study's results, published in the July 15 issue of Circulation, measuring circulating blood levels of C-reactive protein — a marker of inflammation already linked to increased risk of heart disease — may predict who might benefit from a reduced-fat, low-cholesterol diet and who might not.

For the study, a team led by Thomas "Tate" P. Erlinger, M.D., M.P.H., assistant professor of medicine, tracked 100 subjects with elevated CRP levels following a reduced-fat, low-cholesterol diet for 12 weeks. They found that overall, this group had less of a reduction in total cholesterol and low-density lipoprotein (LDL) or "bad" cholesterol levels. Subjects also had a greater increase in triglycerides compared with another group on the same diet but with lower CRP levels.

Subjects with lower CRP readings at the start of the study (less than 2.37 milligrams per liter) had a nearly 10 percent drop in total cholesterol and nearly 12 percent reduction in LDL cholesterol. Their triglycerides were not affected. In those with higher CRP (more than 2.37 mg/L), total and LDL cholesterol were lowered by only 3 percent each, while triglycerides rose by 19 percent.

Erlinger cautions that the study sample was small and did not examine the impact of weight loss on CRP levels.

"An important implication of our findings is that we may be able to use CRP testing to distinguish those who are likely to have a favorable response to a reduced-fat, low-cholesterol diet from those who will not respond well," says Erlinger. "It may also help explain why different people on the same diet may have widely varying results. It's too early for broad recommendations, but additional research in this area could help physicians tailor diets for specific patients."

While causes of inflammation vary, the condition itself has already been linked to several cardiovascular risk factors including hypertension, diabetes and elevated triglycerides. CRP has recently been identified — along with cigarette smoking and obesity — as a risk factor for cardiovascular disease.

The 100 healthy adults in the study had an average age of 52 and already were participating in the national Dietary Approaches to Stop Hypertension-Sodium (DASH-Sodium) trial.

The Hopkins team took blood samples from each participant at the study's start to measure CRP, cholesterol and triglycerides. After two weeks on a control diet of 37 percent total fat and 16 percent saturated fat, participants were assigned to continue to follow either the control diet or the DASH diet, which calls for 27 percent total fat and 6 percent saturated fat, for 12 weeks.

The study was supported by grants from the National Institutes of Health, the National Heart, Lung and Blood Institute and the General Clinical Research Center at Johns Hopkins. Co-authors were Edgar R. Miller III, M.D., Ph.D.; Jeanne Charleston, R.N.; and Lawrence J. Appel, M.D., M.P.H.

- - JHMI - -

Erlinger, Thomas P. et al, "Inflammation Modifies the Effects of a Reduced Fat, Low Cholesterol Diet on Lipids: Results from the DASH-Sodium Trial," Circulation, July 15, 2003; Vol. 108, pages 150-154.

Links:

Johns Hopkins' Welch Center for Prevention, Epidemiology and Clinical Researchhttp://www.med.jhu.edu/welchcenter/

Circulationhttp://circ.ahajournals.org/

Information on the DASH diethttp://www.nhlbi.nih.gov/health/public/heart/hbp/dash/


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Inflammation Blocks Impact Of Heart Healthy Diets For Some." ScienceDaily. ScienceDaily, 24 July 2003. <www.sciencedaily.com/releases/2003/07/030724083515.htm>.
Johns Hopkins Medical Institutions. (2003, July 24). Inflammation Blocks Impact Of Heart Healthy Diets For Some. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2003/07/030724083515.htm
Johns Hopkins Medical Institutions. "Inflammation Blocks Impact Of Heart Healthy Diets For Some." ScienceDaily. www.sciencedaily.com/releases/2003/07/030724083515.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins