Featured Research

from universities, journals, and other organizations

First Big Success For Smallpox Research Project

Date:
October 2, 2003
Source:
University Of Oxford
Summary:
The first stage in finding a treatment for smallpox, a potential threat as a potent weapon of bioterror, is complete. Professor Graham Richards, Chairman of Chemistry at the University of Oxford, together with research and industry partners, will deliver the results of the Smallpox Research Grid project to representatives from the United States Department of Defense.

The first stage in finding a treatment for smallpox, a potential threat as a potent weapon of bioterror, is complete. Professor Graham Richards, Chairman of Chemistry at the University of Oxford, together with research and industry partners, will deliver the results of the Smallpox Research Grid project to representatives from the United States Department of Defense today [Tuesday 30 September].

The smallpox grid project, which was launched in February this year, made use of idle times of home computers around the world in order to find a drug to combat the effects of the smallpox virus after infection. Volunteers from over 190 countries contributed over 39,000 years of computing time in less than six months.

The virus packs its DNA in a tightly coiled form to make it small enough for transport, but needs the enzyme to unwind again in order to replicate. If a molecule can be found to block the enzyme, the virus will not be able to replicate, and the spread of the disease can be halted.

The project screened 35 million potential drug molecules against eight models of the smallpox protein to determine if any of the drug-like molecules would bind to the smallpox protein, rendering it inactivated. Preliminary results have dramatically narrowed the field of molecules that can be considered lead candidates for the next phase of research.

Professor Richards said: 'This represents massive progress in thwarting the threat of smallpox but also a significant opportunity for all life science research. This resource has the potential to find leads against both bioterror and disease agents in a fraction of the time science is accustomed to.

'The smallpox project could also have implications for cancer therapy, as some cancers also have their DNA supercoiled, which means that an enzyme blocker could potentially be used to slow cancer replication and growth.'

Tom Hawk, General Manager at Grid Computing, IBM, said: 'The results of the Smallpox Research Grid are a dramatic illustration of the power of Grid computing to harness the world's computing resources to improve the lives of people around the globe. IBM believes the potential of Grid computing to address similar grand scale research projects is unlimited.'

Notes:

In addition to researchers at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) who funded the project, technologies and services provided by IBM, United Devices, Accelrys, Evotec OAI, Robarts Research Institute, University of Western Ontario, Memorial Sloan Kettering Cancer Research and Essex University were necessary in making the project a success.

Further details about the project can be found on http://www.chem.ox.ac.uk/smallpox/.


Story Source:

The above story is based on materials provided by University Of Oxford. Note: Materials may be edited for content and length.


Cite This Page:

University Of Oxford. "First Big Success For Smallpox Research Project." ScienceDaily. ScienceDaily, 2 October 2003. <www.sciencedaily.com/releases/2003/10/031002060419.htm>.
University Of Oxford. (2003, October 2). First Big Success For Smallpox Research Project. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2003/10/031002060419.htm
University Of Oxford. "First Big Success For Smallpox Research Project." ScienceDaily. www.sciencedaily.com/releases/2003/10/031002060419.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins