Featured Research

from universities, journals, and other organizations

Molecules' Genetic Regulation Altered During Aging

Date:
October 7, 2003
Source:
American Physiological Society
Summary:
A team of researchers has undertaken a study to identify specific molecules whose genetic regulation is altered during aging and that contribute to age-dependent vascular remodeling.

Vascular disease pertains to the disorders that affect our arteries and veins. For the three most common types of vascular disease -- carotid, aortic and peripheral – aging is a major risk factor. Recent studies suggest that pathological changes not only predispose the vasculature to disease but also impair compensatory adaptations to various stimuli including shear force and injury. Other studies have demonstrated a progressive increase in oxidative stress, activation of inflammatory mediators, and increasing endothelial dysfunction in both humans and animals.

Related Articles


Yet individuals and certain rodent strains display different degrees of “physiological aging” at a given chronological age—suggesting a genetic component in the aging process. Aging within the vasculature is characterized by remodeling events similar to those observed in atherosclerosis. Although this vascular aging may predispose the vasculature to disease, the mechanistic basis for this remodeling is presently not understood. One approach to understanding the progressive changes that occur in the vasculature during aging is to evaluate gene expression in vessels that display varying degrees of aging/remodeling. Such a comprehensive genetic analysis would identify specific molecules involved in the aging process. From this analysis novel pathways that regulate the vascular pathologies that develop with aging could be identified as well as potential markers of vascular aging.

A New Study

Against this backdrop a team of researchers has undertaken a study to identify specific molecules whose genetic regulation is altered during aging and that contribute to age-dependent vascular remodeling. Their results are consistent with the current concept that atherosclerosis is an inflammatory process, and suggests that the Fisher 344/Brown Norway F1 hybrid rat (F344xBNrats) may be a good model for studying the vascular changes that occur early in the development of atherosclerosis.

The authors of a new study entitled, “Alterations in Gene Expression During Progressive Aging in Rat Thoracic Aorta,” are Steven J. Miller and Joseph L. Unthank, Methodist Research Institute, Clarian Health, Indianapolis, IN and William C. Watson and Kimberly A. Kerr, Department of Surgery, Indiana University School, of Medicine, Indianapolis, IN. They will present their findings during the upcoming scientific conference, Understanding Renal and Cardiovascular Function Through Physiological Genomics, a meeting of the American Physiological Society (APS) (www.the-aps.org), being held October 1-4, 2003 at the Radisson Riverfront Hotel and Convention Center, Augusta, GA.

Methodology

In their earlier work, the researchers used oligonucleotide microarray analysis to investigate progressive age-mediated changes in gene expressions to demonstrate that vascular remodeling occurs in rat aorta with progressive aging. In the current study, thoracic aorta was harvested from 3-, 6-, 15-, and 28-month old F344xBNrats and total RNA was isolated. Microarray analysis was conducted using a standard protocol. Four biologic replicates were used for each age.

Results

The researchers found:

* that the total number of genes with significant (p<0.01) changes in expression increased with progressive aging compared to 3-month old rats (11, 21, and 277 genes at 6, 15, and 28 months, respectively);

* inflammatory-associated adhesion molecules ICAM-1 and VCAM-1 had significantly (p< 0.01) increased expression at 28 vs. 6 months (2.1x and 3.7x, respectively), as well as 28 vs. 15 months (1.6x and 2.0, respectively);

* ICAM-1/VCAM-1 expression also increased at 15 vs. 6 months, but was not statistically significant; and

* other functional groups of genes that were significantly altered with age at 28 vs. 6 months included increased growth factor expression (FGF-1, TGF-beta-1) and decreased stress protein expression (HSPs 10, 60, 90).

Conclusions

These results demonstrate a progressive age-related increase in thoracic aorta gene expression for adhesion molecules that participate in inflammatory-mediated pathologies, as well as altered expression for selected groups of molecules involved in vascular remodeling.

Next Steps

Future work will investigate differences in gene expression between vessel types and rat strains known to vary in their capacity to remodel during aging. This should allow the researchers to identify additional molecules and pathways involved in the progressive development of vascular pathologies. Accordingly, the results of such studies will provide important new information regarding the genetic basis for vascular aging and lead to additional studies that will identify new targets for diagnosis and interventional therapies for preventing and reversing these pathological changes. This is significant because the majority of current pharmaceuticals was developed for treatment of young, and not aged, adults, who represent a rapidly increasing proportion of the population.

The American Physiological Society (APS) is one of the world’s most prestigious organizations for physiological scientists. These researchers specialize in understanding the processes and functions by which animals live, and thus ultimately underlie human health and disease. Founded in 1887 the Bethesda, MD-based Society has more than 11,000 members and publishes 3,800 articles in its 14 peer-reviewed journals each year.


Story Source:

The above story is based on materials provided by American Physiological Society. Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society. "Molecules' Genetic Regulation Altered During Aging." ScienceDaily. ScienceDaily, 7 October 2003. <www.sciencedaily.com/releases/2003/10/031007061355.htm>.
American Physiological Society. (2003, October 7). Molecules' Genetic Regulation Altered During Aging. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2003/10/031007061355.htm
American Physiological Society. "Molecules' Genetic Regulation Altered During Aging." ScienceDaily. www.sciencedaily.com/releases/2003/10/031007061355.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins