Featured Research

from universities, journals, and other organizations

HIV Vaccine In Worldwide Trial

Date:
October 8, 2003
Source:
Vanderbilt University Medical Center
Summary:
Vanderbilt University Medical Center is participating in worldwide tests of a potential vaccine that can stimulate important immune responses against the virus that causes AIDS. This is the first candidate vaccine against the human immunodeficiency virus (HIV) to be studied simultaneously in so many locations, from Brazil to Thailand, according to Merck & Co. Inc., which developed the vaccine.

Vanderbilt University Medical Center is participating in worldwide tests of a potential vaccine that can stimulate important immune responses against the virus that causes AIDS.

This is the first candidate vaccine against the human immunodeficiency virus (HIV) to be studied simultaneously in so many locations, from Brazil to Thailand, according to Merck & Co. Inc., which developed the vaccine.

Vanderbilt currently is testing six potential AIDS vaccines, but the Merck product has gone farther than any other in generating cellular immune responses in preliminary human tests, says Dr. Paul Spearman, co-principal investigator of the Vanderbilt HIV Vaccine Program, one of nine U.S. sites to participate in the study.

Cellular immune responses refer to the production of a type of white blood cell, known as a cytotoxic or "killer" T-cell, which can clear its virus-infected neighbors from the bloodstream. Scientists believe that by speeding up production of these cells, a vaccine may be able to prevent the virus from spreading in the body.

"It may not prevent infection, but it might stimulate a response that would prevent the disease that results from the infection," Spearman says.

The Vanderbilt program is part of the federally funded HIV Vaccine Trials Network, an international coalition of scientists and institutions dedicated to accelerating the search for an HIV vaccine. This is the first collaboration between Merck and the network. The phase I trial is designed to test – at varying doses -- the vaccine's safety and ability to stimulate immune responses in healthy, uninfected volunteers between the ages of 18 and 50. Of the 435 volunteers who will participate in the study worldwide, about a dozen will be tested at Vanderbilt.

Volunteers will be randomly selected to receive three injections of the either the vaccine or an inactive "placebo." The study involves 24 clinic visits and 22 blood tests over the course of 18 months.

A goal of the study is to see whether a single vaccine can generate significant immune responses in diverse populations throughout the world. If the trial is successful, more extensive testing will be conducted, ultimately leading to studies in people at risk of being infected with HIV.

The research is moving "fairly quickly," Spearman says. "We're really hopeful."

The vaccine consists of a synthetically produced HIV gene – which cannot cause HIV infection. The gene is carried by an adenovirus, which normally can cause symptoms of the common cold, but which has been genetically altered so that is harmless. Side effects of the vaccine in preliminary human studies have been mild. They include soreness at the injection site and, at higher doses than will be used in this study, flu-like symptoms in some people.

###

For more information about volunteering for this or other HIV vaccine trials at Vanderbilt, visit the program's Web site at http://www.hivvaccineresearch.com.


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Vanderbilt University Medical Center. "HIV Vaccine In Worldwide Trial." ScienceDaily. ScienceDaily, 8 October 2003. <www.sciencedaily.com/releases/2003/10/031008064551.htm>.
Vanderbilt University Medical Center. (2003, October 8). HIV Vaccine In Worldwide Trial. ScienceDaily. Retrieved September 29, 2014 from www.sciencedaily.com/releases/2003/10/031008064551.htm
Vanderbilt University Medical Center. "HIV Vaccine In Worldwide Trial." ScienceDaily. www.sciencedaily.com/releases/2003/10/031008064551.htm (accessed September 29, 2014).

Share This



More Health & Medicine News

Monday, September 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Why Is Big Tobacco Voluntarily Warning You About E-Cigs?

Why Is Big Tobacco Voluntarily Warning You About E-Cigs?

Newsy (Sep. 29, 2014) Big tobacco companies are voluntarily printing health warnings on their e-cigarette packages — a move some are calling part of a PR strategy. Video provided by Newsy
Powered by NewsLook.com
Why Pediatricians Endorse IUDs, Implants For Teens

Why Pediatricians Endorse IUDs, Implants For Teens

Newsy (Sep. 29, 2014) New recommendations from the American Academy of Pediatrics point to intrauterine devices and implants as good forms of birth control for teens. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins