Featured Research

from universities, journals, and other organizations

New Penn Study Shows Genes May Influence Smoking Cessation

Date:
October 14, 2003
Source:
University Of Pennsylvania Medical Center
Summary:
Smokers with a specific combination of two genetic variants may be more likely to remain abstinent and less prone to relapse when trying to quit smoking, a study by researchers from the Tobacco Use Research Center of the University of Pennsylvania School of Medicine indicates.

Philadelphia, PA -- Smokers with a specific combination of two genetic variants may be more likely to remain abstinent and less prone to relapse when trying to quit smoking, a study by researchers from the Tobacco Use Research Center of the University of Pennsylvania School of Medicine indicates. This research – which will appear in the October issue of Health Psychology- has important implications for the development of more effective treatment strategies that are tailored to individual smokers' needs.

"While previous research has examined the effects of genes related to dopamine, a chemical in the brain associated with reinforcing the effects of nicotine, this study provides the first evidence that genes that alter dopamine function may influence smoking cessation and relapse during treatment," said lead author Caryn Lerman, Ph.D., Associate Director for Cancer Control and Population Science at the Abramson Cancer Center of the University of Pennsylvania and Professor in Penn's School of Medicine and the Annenberg Public Policy Center.

Dr. Lerman led a research team that examined 418 smokers enrolled in a randomized placebo-controlled clinical trial of bupropion for smoking cessation. Participants provided blood samples and received bupropion or placebo plus seven sessions of behavioral group counseling. Smoking status, abstinence symptoms and side effects were recorded weekly, and smoking status was verified at the end of treatment and again at a six-month follow-up appointment.

Researchers found that participants with particular variants of the SLC6A3 dopamine transporter gene and the DRD2 dopamine receptor gene reported significantly higher abstinences rates and a longer time before relapse than smokers carrying other variants of these genes. "This gene-gene interaction provides new evidence for the effects of dopamine genes on prospective smoking cessation and underscores the importance of not limiting genetic investigations of smoking behavior to single gene effects," said Lerman.

In previous research, the same variant of the dopamine transporter gene has been associated with higher levels of dopamine in the brain and this may facilitate smoking cessation. "Future smoking cessation studies should evaluate genetic predisposition, as well as the influence of psychological and environmental factors that may promote relapse," stated Lerman.

This research will appear in Health Psychology in an article titled "Effects of Dopamine Transporter and Receptor Polymorphisms on Smoking Cessation in a Bupropion Clinical Trial."

This research was funded by the National Cancer Institute and the National Institute on Drug Abuse and was conducted by the University of Pennsylvania/Georgetown University Transdisciplinary Tobacco Use Research Center.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "New Penn Study Shows Genes May Influence Smoking Cessation." ScienceDaily. ScienceDaily, 14 October 2003. <www.sciencedaily.com/releases/2003/10/031012234908.htm>.
University Of Pennsylvania Medical Center. (2003, October 14). New Penn Study Shows Genes May Influence Smoking Cessation. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2003/10/031012234908.htm
University Of Pennsylvania Medical Center. "New Penn Study Shows Genes May Influence Smoking Cessation." ScienceDaily. www.sciencedaily.com/releases/2003/10/031012234908.htm (accessed July 22, 2014).

Share This




More Mind & Brain News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Obese Women Have 'Food Learning Impairment'?

Do Obese Women Have 'Food Learning Impairment'?

Newsy (July 18, 2014) Yale researchers tested 135 men and women, and it was only obese women who were deemed to have "impaired associative learning." Video provided by Newsy
Powered by NewsLook.com
Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Newsy (July 18, 2014) A new study suggests that mixing alcohol with energy drinks makes you want to keep the party going. Video provided by Newsy
Powered by NewsLook.com
Pot Cooking Class Teaches Responsible Eating

Pot Cooking Class Teaches Responsible Eating

AP (July 18, 2014) Following the nationwide trend of eased restrictions on marijuana use, pot edibles are growing in popularity. One Boston-area cooking class is teaching people how to eat pot responsibly. (July 18) Video provided by AP
Powered by NewsLook.com
Understanding D.C.'s New Pot Laws

Understanding D.C.'s New Pot Laws

Newsy (July 17, 2014) Washington D.C.'s new laws decriminalizing small amount of marijuana went into effect Thursday. Here's how they work. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins