Featured Research

from universities, journals, and other organizations

Storing Too Much Iron May Put Healthy Women At Increased Risk For Type 2 Diabetes

Date:
February 13, 2004
Source:
Journal Of The American Medical Association
Summary:
Higher amounts of iron stores in the blood are associated with an increased risk of type 2 diabetes in healthy women who have no known diabetes risk factors, according to a study in the February 11, 2004 issue of The Journal of the American Medical Association (JAMA).

Higher amounts of iron stores in the blood are associated with an increased risk of type 2 diabetes in healthy women who have no known diabetes risk factors, according to a study in the February 11, 2004 issue of The Journal of the American Medical Association (JAMA).

Related Articles


Excessive iron stores can cause type 2 diabetes among patients with hemochromatosis, a genetic defect in the regulation of iron absorption, according to background information in the article. However, the authors write that it is not clear if moderately elevated iron stores predict the risk of developing type 2 diabetes among healthy individuals. The authors note that iron excess seems to contribute initially to insulin resistance and subsequently to decreased insulin secretion.

Rui Jiang, M.D., Dr.P.H., from the Harvard School of Public Health, Boston, and colleagues, evaluated biomarkers reflecting iron stores, including plasma ferritin (an iron-protein complex in blood) concentration and the ratio of the concentrations of transferrin receptors (iron transporters) to ferritin in relation to the development of type 2 diabetes in apparently healthy middle-aged women enrolled in the Nurses' Health Study. Of the 32,826 women who provided blood samples during 1989 - 1990 and were free of diagnosed diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. The researchers randomly selected 716 women from the study to be in the control group who were free from diabetes.

"Overall, women who subsequently developed diabetes during follow-up were heavier, more likely to have a family history of diabetes, less likely to exercise and consume alcohol, and had higher plasma concentrations of CRP (C-Reactive Protein - a biomarker for inflammation), fasting insulin, and hemoglobin A1c at baseline," the authors found. "In addition, diabetic women tended to have higher baseline average intake of heme iron [a type of iron], transfat, red and processed meats, total calories, and lower intake of cereal fiber and magnesium. ... At baseline, the mean (average) ferritin concentration was significantly higher (109 vs. 71.5 ng [nanograms]/mL [milliliter]) and the mean ratio of transferrin receptors to ferritin was significantly lower (102 vs. 141) in the cases [those with type 2 diabetes] than in the healthy controls."

In conclusion the authors write, "This finding may have important implications for the prevention of type 2 diabetes because elevated ferritin concentration and lower concentration in the ratio of transferrin receptors to ferritin in healthy populations may help to identify a high-risk population for type 2 diabetes who may benefit from further evaluation and interventions (lifestyle or therapeutic)."

###

(JAMA. 2004;291:711-717. Available post-embargo at http://JAMA.com.)

Editor's Note: This work was supported by research grants from the National Institutes of Health. Co-author Dr. Meigs is supported in part by a Career Development Award from the American Diabetes Association.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Storing Too Much Iron May Put Healthy Women At Increased Risk For Type 2 Diabetes." ScienceDaily. ScienceDaily, 13 February 2004. <www.sciencedaily.com/releases/2004/02/040212085111.htm>.
Journal Of The American Medical Association. (2004, February 13). Storing Too Much Iron May Put Healthy Women At Increased Risk For Type 2 Diabetes. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2004/02/040212085111.htm
Journal Of The American Medical Association. "Storing Too Much Iron May Put Healthy Women At Increased Risk For Type 2 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2004/02/040212085111.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins