Featured Research

from universities, journals, and other organizations

Tumor Suppressor Genes Predict Bladder Cancer Future

Date:
March 18, 2004
Source:
Baylor College Of Medicine
Summary:
The presence of two mutated genes in bladder cancer tumors indicates there is a high risk that the cancer will continue grow and spread, said a Baylor College of Medicine (BCM) researcher in a report released in the March 15 issue of the Journal of Clinical Oncology.

The presence of two mutated genes in bladder cancer tumors indicates there is a high risk that the cancer will continue grow and spread, said a Baylor College of Medicine (BCM) researcher in a report released in the March 15 issue of the Journal of Clinical Oncology.

One of the mutated proteins – p53 – is a tumor suppressor that in its normal form prevents cell changes that can lead to cancer. When p53 binds to DNA is stimulates another gene to produce p21. Then p21 interacts with a protein that stimulates cell division. When p21 is in a complex with this protein, the cell cannot go through the next stage of division. Mutations in the genes prevent these protective mechanisms.

In this study, Dr. Seth Lerner, associate professor urology at BCM, evaluated the roles of four gene alterations in the tumors of 80 bladder cancer patients. They found that one of the genes was altered in 83 percent of patients.

However, p53 proved the strongest predictor that the cancer would progress and p21 was the next strongest. This indicates that these genes play an important role in the development of this disease and should be more closely studied, said Lerner in his paper.

Others who participated in the study came from the Methodist Hospital in Houston, The University of Texas M.D. Anderson Cancer Center, Houston; and The University of Texas Southwestern Medical Center, Dallas, TX.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Tumor Suppressor Genes Predict Bladder Cancer Future." ScienceDaily. ScienceDaily, 18 March 2004. <www.sciencedaily.com/releases/2004/03/040317073445.htm>.
Baylor College Of Medicine. (2004, March 18). Tumor Suppressor Genes Predict Bladder Cancer Future. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2004/03/040317073445.htm
Baylor College Of Medicine. "Tumor Suppressor Genes Predict Bladder Cancer Future." ScienceDaily. www.sciencedaily.com/releases/2004/03/040317073445.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins