Featured Research

from universities, journals, and other organizations

Germany Starts Clinical Development Of A New Tuberculosis Vaccine

Date:
March 26, 2004
Source:
Max Planck Society
Summary:
To mark World Tuberculosis Day on March 24th, a consortium of business and research centres have launched a programme to develop just such a vaccine.

Macrophages and tuberculosis bacteria. Macrophages are among the most important defense protection of the body. Tuberculosis bacteria however "hide" in the macrophages and are thus able to survive.
Credit: Image : MPI for Infection Biology/Volker Brinkmann

To mark World Tuberculosis Day on March 24th, a consortium of business and research centres have launched a programme to develop just such a vaccine. Scientists at the Max Planck Institute for Infection Biology (MPIIB) in Berlin, under the direction of Prof. Stefan H. E. Kaufmann, have developed a highly promising vaccine candidate. And now, Vakzine Projekt Management GmbH (VPM) has acquired a worldwide licence for several patents from Max Planck Society. VPM was founded by Germany's Federal Ministry for Education and Research (BMBF) as part of a national vaccine initiative. In collaboration with MPIIB and the German Rearch Centre for Biotechnology (GBF) VPM will manage the pre-clinical and clinical study program.

Related Articles


"For our new tuberculosis vaccine candidates we are relying on genetically modified variants of the live BCG vaccine that has been in use since 1921," says MPI director, Prof. Dr. Stefan Kaufmann. "The vaccine consists of an attenuated bacteria that is very closely related to the TB pathogen, Mycobacterium tuberculosis. BCG has a proven safety record for many decades, but unfortunately it lacks effectiveness," notes Kaufmann, adding that children can be protected against certain forms of TB only. There is no protection at all against pneumotuberculosis, by far the most common form of the disease.

The protection provided by the presently existing BCG vaccine is assumed to be limited because the BCG bacteria are hidden in the body cells inside so-called phagosomes. The group of Professor Kaufmann, therefore, has inserted a gene coding for the protein listeriolysin. "This protein causes perforation of the phagosomes thus making BCG cells available to the immune system to build up immune protection," says Dr. Leander Grode, now project manager at VPM and co-inventor of the new strain. "Preclinical experiments have already indicated an increased immune response," he notes.

Estimates suggest that one third of the world's population is infected with TB bacteria. Initially, the pathogens are dormant. The disease later erupts in about 10 percent of those infected, who develop open, contagious tuberculosis. With more than 7,500 cases annually in Germany the disease is nowhere near eradication. "Medical need is high and on the rise with the spread of multi-resistant strains," emphasises VPM Managing Director, Dr. Albrecht Lδufer, "therefore, a successful TB vaccine has considerable economic potential." VPM's goal is development up to Phase II, followed by licencing out to an industrial partner. Joint early stage development with partners is also under consideration.

Project Partners

Vakzine Projekt Management GmbH (http://www.vakzine-manager.de) in Braunschweig organises and finances pre-clinical and clinical development of vaccines and related products nationwide. VPM was founded as part of the vaccine initiative of Germany's Federal Ministry for Education and Research (BMBF).

The Max Planck Institute for Infection Biology (http://www.mpiib-berlin.mpg.de) in Berlin studies the disease mechanisms found in a variety of medically relevant pathogens. One area of focus is tuberculosis.

The German Research Centre for Biotechnology (http://www.gbf.de) in Braunschweig is the Helmholtz centre for Infection Research and official project holder of the vaccine initiative of BMBF.


Story Source:

The above story is based on materials provided by Max Planck Society. Note: Materials may be edited for content and length.


Cite This Page:

Max Planck Society. "Germany Starts Clinical Development Of A New Tuberculosis Vaccine." ScienceDaily. ScienceDaily, 26 March 2004. <www.sciencedaily.com/releases/2004/03/040325074523.htm>.
Max Planck Society. (2004, March 26). Germany Starts Clinical Development Of A New Tuberculosis Vaccine. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2004/03/040325074523.htm
Max Planck Society. "Germany Starts Clinical Development Of A New Tuberculosis Vaccine." ScienceDaily. www.sciencedaily.com/releases/2004/03/040325074523.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins