Featured Research

from universities, journals, and other organizations

Jefferson Researchers Discover Novel Gene Profile That May Identify Colon Stem Cells

Date:
March 30, 2004
Source:
Thomas Jefferson University
Summary:
Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny "crypts" in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the development of colon cancer.

Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny "crypts" in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the development of colon cancer.

Related Articles


"Having a genetic signature for the colonic stem cell will give us a tool to investigate the hypothesis that stem cell overpopulation is the key to colon cancer initiation," says Bruce Boman, M.D., Ph.D., director of the Division of Genetic and Preventive Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia and Jefferson's Kimmel Cancer Center, who led the work. Dr. Boman presents his team's findings March 30 at the annual meeting of the American Association for Cancer Research in Orlando. According to Dr. Boman, a form of inherited colon cancer, familial adenomatous polyposis, or FAP, may begin when processes that regulate adult stem cells in the colon go awry. To try to understand some of these processes, Dr. Boman and his team decided to first look at the genes expressed in normal colon crypts.

The researchers examined sections of the top, middle and bottom of crypts, using microarray technology to analyze which genes are selectively expressed in each region. They were particularly interested in the genes expressed in the bottom of the crypt, where the stem cells reside.

"We've found some intriguing patterns of gene expression – patterns that suggest a unique genetic signature for stem cells," says research technician Moreh Salunek. "We were looking at genes that were unique and up-regulated in the bottom of the crypt, and found that the majority were related to binding processes and catalytic enzymes." Some were surprising, she says, such as STAMP1, a gene implicated as a marker for the progression of prostate cancer. They also found a gene called HOXD4, which is a developmental gene involved in the formation of the gut.

Stem cells in the normal colon produce daughter cells that proliferate and make their way to the crypt top, where they differentiate into specialized colon cells, says Dr. Boman. Colon cancer is marked by a change in the distribution pattern of proliferating daughter cells. Next, the researchers plan to use their novel gene profile to investigate cellular changes in colon cancer development. They also plan to use a different microarray to expand the number of genes they can examine.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Jefferson Researchers Discover Novel Gene Profile That May Identify Colon Stem Cells." ScienceDaily. ScienceDaily, 30 March 2004. <www.sciencedaily.com/releases/2004/03/040330084254.htm>.
Thomas Jefferson University. (2004, March 30). Jefferson Researchers Discover Novel Gene Profile That May Identify Colon Stem Cells. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2004/03/040330084254.htm
Thomas Jefferson University. "Jefferson Researchers Discover Novel Gene Profile That May Identify Colon Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2004/03/040330084254.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins