Featured Research

from universities, journals, and other organizations

Deleting Neural STAT3 Protein In Mice Causes Extreme Obesity, Diabetes And Infertility

Date:
April 5, 2004
Source:
Yale University
Summary:
Protein molecules that help maintain a healthy body temperature, electrolyte balance, respiration, heart rate, and other critical functions, also appear to regulate weight and fertility, according to Yale researchers.

New Haven, Conn. -- Protein molecules that help maintain a healthy body temperature, electrolyte balance, respiration, heart rate, and other critical functions, also appear to regulate weight and fertility, according to Yale researchers.

Related Articles


STAT3 proteins are regulatory molecules that signal cell functions for activating genes. When the STAT3 molecules are disrupted in mice, the animals either die before they are born, or overeat and become obese, diabetic and infertile, according to the study published in the Proceedings of the National Academy of Sciences.

Mice with disrupted STAT3 begin to gain weight at six to eight weeks old and weigh twice as much as normal mice by adulthood. The excess body mass was almost exclusively fat. Livers of the mice also were severely enlarged with fat deposits.

The senior author, Xin-Yuan Fu, of the Department of Pathology at Yale School of Medicine, said the study contradicts previous research that concluded STAT3 plays no role in reproduction and growth and only a marginal role in glucose regulation.

The study also raises more questions about leptin, a protein produced by fat cells and thought to play an important role in signaling the reduction of body fat.

"The mutant mice had an oversupply of leptin, yet still became obese, suggesting a leptin-resistant condition," Fu said.

During embryonic development, STAT3 is found in areas of the brain where nerve cell proliferation and differentiation take place. In adults, STAT3 has been implicated in the regulation of energy balance through its effect on leptin. This new study provides direct evidence for this role.

Fu said the study shows that body weight and fertility are essentially controlled through STAT3 functions in the brain. These discoveries, he said, could help in the development of new therapeutics to treat obesity and infertility.

###

Citation: Proceedings of the National Academy of Sciences, Vol. 101: 4661-4666 (March 30, 2004)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Deleting Neural STAT3 Protein In Mice Causes Extreme Obesity, Diabetes And Infertility." ScienceDaily. ScienceDaily, 5 April 2004. <www.sciencedaily.com/releases/2004/04/040405092542.htm>.
Yale University. (2004, April 5). Deleting Neural STAT3 Protein In Mice Causes Extreme Obesity, Diabetes And Infertility. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2004/04/040405092542.htm
Yale University. "Deleting Neural STAT3 Protein In Mice Causes Extreme Obesity, Diabetes And Infertility." ScienceDaily. www.sciencedaily.com/releases/2004/04/040405092542.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins