Featured Research

from universities, journals, and other organizations

Dental Pulp Cells May Hold Key To Treatment Of Parkinson's Disease

Date:
May 5, 2004
Source:
University Of Michigan
Summary:
Cells derived from the inside of a tooth might someday prove an effective way to treat the brains of people suffering from Parkinson's disease.

ANN ARBOR, Mich. -- Cells derived from the inside of a tooth might someday prove an effective way to treat the brains of people suffering from Parkinson's disease.

Related Articles


A study in the May 1 issue of the European Journal of Neuroscience shows dental pulp cells provide great support for nerve cells lost in Parkinson's disease and could be transplanted directly into the affected parts of the brain. The study's lead author is Christopher Nosrat, an assistant professor of biological and materials sciences at the University of Michigan School of Dentistry.

This is not the first test of stem cells as a therapy for Parkinson's disease-type illnesses, known as neurodegenerative diseases, but Nosrat noted that it is the first to use post-natal stem cells grown from more readily available tooth pulp in the nervous system.

Using dental pulp has other advantages besides its availability, Nosrat said. The cells produce a host of beneficial "neurotrophic" factors, which promote nerve cell survival.

Parkinson's disease is characterized by symptoms including tremors of the hands, arms or legs, rigidity of the body and difficulty balancing while standing or walking. Parkinson's affects nerve cells in the part of the brain called the basal ganglia, which is responsible for control of voluntary movement. An estimated 1 million Americans suffer from Parkinson's disease, for which there is no cure.

Nosrat's study involved evaluating the potential of injecting tooth cells into brain cells as a possible cell-based therapy for Parkinson's. He was testing whether the tooth cells could provide neurotrophic factors to support dying nerve cells and replace dead cells.

Nosrat also has studied dental pulp stem cells as a treatment for spinal cord injuries and said applying that knowledge to treatment of neurodegenerative disease was the next logical step.

He used the same general approach for this Parkinson's study: researchers extract a tooth and draw cells from the center of the tooth, then culture them in a Petri dish to increase the number of the cells. The cell mixture then contains neuronal precursor cells and cells that produce beneficial neurotrophic factors.

Nosrat emphasized that there is much work to be done before human patients might find relief from Parkinson's symptoms as a result of this therapy. It is still many years from being tested in people as a possible treatment or cure for neurological disorders.

Previous studies have used other sources for stem cells, and in animal and human studies, most of those cells die when grafted into the brain. Nosrat believes cells drawn from dental pulp are more robust because they also produce the neurotrophic factors, which promote nerve cell survival. Nosrat hopes that by refining the delivery method—by focusing the treatment much more specifically on affected parts of the brain and the co-delivery of neurotrophic factors—he can eventually achieve success.

European Journal of Neuroscience is the official journal for the federation of European neuroscience societies: http://www.blackwellpublishing.com/journal.asp?ref=0953-816X&site=1 The article is titled "Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro, implications for tissue engineering and repair in the nervous system."

Nosrat's co-authors are his wife, Irina Nosrat, Christopher Smith and Patrick Mullally, at the U-M School of Dentistry, and Lars Olson at the Karolinksa Institutet in Stockholm, Sweden.

Partial funding for the study came from the National Institute of Dental and Craniofacial Research, part of the National Institutes of Health, as well as from the Michigan Parkinson's Foundation.

Nosrat's faculty profile: http://bms.dent.umich.edu/people/nosrat.html

A release on Nosrat's work in spinal cord injuries: http://www.umich.edu/~newsinfo/Releases/2001/Sep01/r090401.html


Story Source:

The above story is based on materials provided by University Of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University Of Michigan. "Dental Pulp Cells May Hold Key To Treatment Of Parkinson's Disease." ScienceDaily. ScienceDaily, 5 May 2004. <www.sciencedaily.com/releases/2004/05/040505065427.htm>.
University Of Michigan. (2004, May 5). Dental Pulp Cells May Hold Key To Treatment Of Parkinson's Disease. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2004/05/040505065427.htm
University Of Michigan. "Dental Pulp Cells May Hold Key To Treatment Of Parkinson's Disease." ScienceDaily. www.sciencedaily.com/releases/2004/05/040505065427.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins