Featured Research

from universities, journals, and other organizations

Scientists Discover Way To Regulate The Body's Energy Expenditure

Date:
June 4, 2004
Source:
Imperial College Of Science, Technology And Medicine
Summary:
Scientists have discovered a protein that controls the amount of fat stored in the body, offering new clues for obesity treatments.

Scientists have discovered a protein that controls the amount of fat stored in the body, offering new clues for obesity treatments.

The research, published in this week's Proceedings of the National Academy of Sciences, shows how the protein regulates the activity of a key gene responsible for maintaining the body's temperature, called uncoupling protein 1 (UCP1).

The new protein, called RIP140, blocks the expression of UCP1, and causes the body to use up more energy and store less fat.

The team of scientists from Imperial College London, Kings College London, University of Cambridge, and Hammersmith Hospital, UK, conducted studies in transgenic mice born without RIP140, and in normal mice with RIP140. They found that mice without RIP140 were lean and showed resistance to high fat diet induced obesity.

On average, mice without RIP140 were 20 per cent lighter compared with normal mice and accumulated between 50 and 70 per cent less fat when compared with mice with RIP140, even though their food intake was similar.

Professor Malcolm Parker from Imperial College London, and based at Hammersmith Hospital, and one of the study's authors comments: "This discovery could provide a novel approach to developing new obesity treatments. By reducing the levels of RIP140, it is possible to increase the activity of the UCP1 gene. UCP1 plays a key role in regulating energy balance in the body, and through this we can reduce body weight by increasing energy expenditure.

"Although these are very promising observations we do need to be careful in interpreting the results. The study was carried out in mice, which were born without RIP140, and it will be important to determine the consequences of blocking RIP140 action in adult animals."

This work was supported by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council. Professor Parker and his team have recently signed a deal with CytRx, a US based biopharmaceutical company, to commercialise the results of this research.


Story Source:

The above story is based on materials provided by Imperial College Of Science, Technology And Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College Of Science, Technology And Medicine. "Scientists Discover Way To Regulate The Body's Energy Expenditure." ScienceDaily. ScienceDaily, 4 June 2004. <www.sciencedaily.com/releases/2004/06/040603070101.htm>.
Imperial College Of Science, Technology And Medicine. (2004, June 4). Scientists Discover Way To Regulate The Body's Energy Expenditure. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2004/06/040603070101.htm
Imperial College Of Science, Technology And Medicine. "Scientists Discover Way To Regulate The Body's Energy Expenditure." ScienceDaily. www.sciencedaily.com/releases/2004/06/040603070101.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins