Featured Research

from universities, journals, and other organizations

Earliest Evidence Of Hereditary Genetic Disorder Discovered

Date:
June 29, 2004
Source:
Hebrew University Of Jerusalem
Summary:
The discovery of what is believed to be the oldest evidence yet found of a human hereditary genetic disorder has been announced by researchers at the Hebrew University of Jerusalem.

View of the lower jaw of the prehistoric child from Ethiopia, showing the tooth (at left) with abnormal shape resulting from amelogensis imperfecta.
Credit: Photo courtesy of Hebrew University Of Jerusalem

The discovery of what is believed to be the oldest evidence yet found of a human hereditary genetic disorder has been announced by researchers at the Hebrew University of Jerusalem.

Related Articles


The researchers are Dr. Uri Zilberman and Patricia Smith, the Joel Wilbush Professor of Medical Anthropology, both of the Faculty of Dental Medicine of the Hebrew University and Dr. Silvana Condemi a senior researcher at the French Research Institute in Jerusalem. They are among the authors of an article in the June issue of the Journal of Human Evolution that details the finding of a disease known as amelogenesis imperfecta in the teeth of a fossil found in archaeological excavations in Ethiopia. The fossil is dated as 1.5 million years old and is from a two-year-old Homo erectus child. Homo erectus was a precursor of modern man.

According to Dr.Zilberman, this is the first recorded evidence from such an early prehistoric period of a hereditary disorder in which the specific genes responsible have been identified. Undoubtedly, he said, there are other hereditary diseases that have come down to us from prehistoric ancestors and which are yet to be discovered in fossil remains.

Amelogenesis imperfecta is a hereditary disorder that manifests itself in tooth enamel that is abnormal in structure, low in mineral content and hence subject to rapid wear and chipping. The Hebrew University researchers confirmed the clear presence of the disease in the fossil sample through x-ray and scanning electron microscope analyses. The disease appears relatively rarely today (one in 14,000 people in Israel, one in 8,000 in the U.S.). It is much more common in one area of Sweden (one in 700).

Dr. Zilberman and Prof. Smith are paleoanthropologists in the Laboratory of Bioanthropology and Ancient DNA at the Hebrew University Faculty of Dental Medicine.

Also among the authors of the article in the Journal of Human Evolution is Prof. Marcello Piperno of the University of Rome.


Story Source:

The above story is based on materials provided by Hebrew University Of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University Of Jerusalem. "Earliest Evidence Of Hereditary Genetic Disorder Discovered." ScienceDaily. ScienceDaily, 29 June 2004. <www.sciencedaily.com/releases/2004/06/040629020352.htm>.
Hebrew University Of Jerusalem. (2004, June 29). Earliest Evidence Of Hereditary Genetic Disorder Discovered. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2004/06/040629020352.htm
Hebrew University Of Jerusalem. "Earliest Evidence Of Hereditary Genetic Disorder Discovered." ScienceDaily. www.sciencedaily.com/releases/2004/06/040629020352.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Fossils & Ruins News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gallery Takes Two Years to Carefully Repair Hole Punched in $12 Million Monet

Gallery Takes Two Years to Carefully Repair Hole Punched in $12 Million Monet

Buzz60 (Jan. 26, 2015) An Irish art gallery details the extensive surgery a priceless Monet underwent after being punched by some crazy Irish guy. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
India Clears Cows, Dogs, Dust for Obama Taj Mahal Trip

India Clears Cows, Dogs, Dust for Obama Taj Mahal Trip

AFP (Jan. 23, 2015) Preparations are under way at the Taj Mahal ahead of a visit by Barack and Michelle Obama. Duration: 01:11 Video provided by AFP
Powered by NewsLook.com
Lincoln Collection to Be Auctioned in Dallas

Lincoln Collection to Be Auctioned in Dallas

AP (Jan. 23, 2015) Hundreds of pieces of Lincoln memorabilia collected by a Fort Worth, Texas businessman are set to be auctioned this weekend. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Phones Used 100 Years Ago on Display

Phones Used 100 Years Ago on Display

AP (Jan. 22, 2015) The phones used to make the world&apos;s first coast-to-coast conference call 100 years ago have been put on display at the California Historical Society&apos;s 1915 World&apos;s Fair exhibit space in San Francisco. (Jan. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins