Featured Research

from universities, journals, and other organizations

Study Assesses Tomato Oil Effect On Prostate

Date:
November 19, 2004
Source:
Northwestern University
Summary:
A new study at Northwestern University seeks to determine whether natural tomato oil with a high concentration of lycopene may reverse or delay progression of high-grade prostatic intraepithelial neoplasia (HGPIN), a condition in which abnormal cells form within the prostate and which is the strongest risk factor yet identified for the development of prostate cancer.

CHICAGO --- Lycopene, an antioxidant commonly found in tomatoes and tomato-based products, is commonly perceived to reduce the risk of developing prostate cancer.

A new study at Northwestern University seeks to determine whether natural tomato oil with a high concentration of lycopene may reverse or delay progression of high-grade prostatic intraepithelial neoplasia (HGPIN), a condition in which abnormal cells form within the prostate and which is the strongest risk factor yet identified for the development of prostate cancer.

The study is headed by Peter Gann, M.D., professor of preventive medicine at the Northwestern University Feinberg School of Medicine and a member of the cancer epidemiology and prevention program at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Lycopene has been found to have anti-tumor activity in a number of laboratory studies. Also, it has been used in a number of cancer studies in humans (e.g., lung, stomach and prostate cancers) that demonstrated a lower cancer rate in people with a high dietary intake of lycopene.

Research has shown an over 20 percent reduced risk for developing prostate cancer in men who ate more cooked tomato products, such as tomato sauce. Additional studies showed that cooking tomatoes and eating them with oil substantially increases the bioavailability of lycopene.

The National Cancer Institute-sponsored study at Northwestern will use tomato extract (literally, tomato oil) from non-genetically modified tomatoes raised in Israel and specially grown to be high in lycopene content.

Results of the study will be useful for clarifying the mechanisms of action of lycopene in the prostate, for designing phase III clinical studies and, more generally, for determining the chemopreventive potential of this relatively non-toxic dietary compound.

Prostate cancer is the most commonly diagnosed cancer among men in the United States, amounting to an expected 230,100 new cases and 29,900 deaths in 2004, according to the American Cancer Society.

“Prostate cancer is a rational target for chemoprevention because of its high public health burden and relatively slow growth rate,” Gann said.

“Although early surgical treatment of prostate cancer might be effective, it involves substantial discomfort. This, plus the wide variability in the biological behavior of prostate cancer, makes overtreatment a persistent and serious concern,” Gann said.

To qualify for the lycopene HGPIN study, participants must be men age 40 and older; have had a biopsy indicating HGPIN without cancer within the last two years; be ambulatory, capable of self-care and able to perform light or sedentary work; be willing to limit intake of lycopene-containing foods, as well as supplements containing lycopene during the study period; have no prior cancer (except basal cell or squamous cell skin cancer) or complete remission for at least five years.

For information on the lycopene HGPIN study, call (312) 908-8421.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Study Assesses Tomato Oil Effect On Prostate." ScienceDaily. ScienceDaily, 19 November 2004. <www.sciencedaily.com/releases/2004/11/041116233133.htm>.
Northwestern University. (2004, November 19). Study Assesses Tomato Oil Effect On Prostate. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2004/11/041116233133.htm
Northwestern University. "Study Assesses Tomato Oil Effect On Prostate." ScienceDaily. www.sciencedaily.com/releases/2004/11/041116233133.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins