Featured Research

from universities, journals, and other organizations

New Herpes Vaccine May Be Ready For Human Trials

Date:
January 6, 2005
Source:
American Society For Microbiology
Summary:
New research suggests that a promising herpes vaccine may be ready for testing in humans say researchers from the National Institutes of Health and Harvard Medical School. Their findings appear in the January 2005 issue of the Journal of Virology.

New research suggests that a promising herpes vaccine may be ready for testing in humans say researchers from the National Institutes of Health and Harvard Medical School. Their findings appear in the January 2005 issue of the Journal of Virology.

Herpes simplex virus type 2 (HSV-2), or genital herpes, is a virus that infects approximately 22% of adult Americans. Bearing physical, psychological, and social effects on those who acquire it, it can pose an even more severe risk for immuno-compromised patients further emphasizing the need for an effective vaccine.

“In the aggregate, the burden of genital herpes has made development of more effective prevention strategies a health priority,” say the researchers.

The study compared three different vaccines, a DNA vaccine, an antigenic vaccine and a live mutant strain of the type 2 virus, d15-29, in mice and guinea pigs. The live mutant strain, d15-29, showed minimal risk of causing disease as it is missing two of the genes necessary for replication and it stimulated a stronger immune response in both animals.

“Given its efficacy, its defectiveness for latency, and its ability to induce rapid, virus-specific CD8+-T-cell responses, the dl5-29 vaccine may be a good candidate for early-phase human trials,” say the researchers.

(Y. Hoshino, S.K. Dalai, K. Wang, L. Pesnicak, T.Y. Lau, D.M. Knipe, J.I. Cohen, S.E. Straus. 2004. Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs. Journal of Virology, 79. 1: 410-418.)


Story Source:

The above story is based on materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society For Microbiology. "New Herpes Vaccine May Be Ready For Human Trials." ScienceDaily. ScienceDaily, 6 January 2005. <www.sciencedaily.com/releases/2005/01/050104112342.htm>.
American Society For Microbiology. (2005, January 6). New Herpes Vaccine May Be Ready For Human Trials. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2005/01/050104112342.htm
American Society For Microbiology. "New Herpes Vaccine May Be Ready For Human Trials." ScienceDaily. www.sciencedaily.com/releases/2005/01/050104112342.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins