Featured Research

from universities, journals, and other organizations

Patients With Cancer Have Highly Increased Risk For Blood Clots

Date:
February 16, 2005
Source:
Urnal Of The American Medical Association
Summary:
Patients with cancer have a 7-fold increased risk for blood clots in the legs or lungs (venous thrombosis), according to a study in the February 9 issue of JAMA.

Patients with cancer have a 7-fold increased risk for blood clots in the legs or lungs (venous thrombosis), according to a study in the February 9 issue of JAMA.

Related Articles


Studies that identify patients at highest risk of thrombosis are scarce, according to background information in the article. It is unclear what risks are for various types and stages of cancer.

Jeanet W. Blom, M.D., of the Leiden University Medical Center, Leiden, the Netherlands, and colleagues conducted a study to identify individuals with cancer with an increased thrombotic risk, evaluated different tumor sites, the presence of distant metastases, and carrier status of gene mutations. The study (Multiple Environmental and Genetic Assessment [MEGA]) included 3,220 patients, aged 18 to 70 years, with a first deep venous thrombosis of the leg or pulmonary embolism (blood clot in the lungs), between March 1, 1999, and May 31, 2002, at 6 anticoagulation clinics in the Netherlands. There were 2,131 control participants (partners of the patients). Both groups reported via a questionnaire on acquired risk factors for venous thrombosis. Three months after discontinuation of the anticoagulant therapy, all patients and controls were interviewed, a blood sample was taken, and DNA was isolated to ascertain the gene mutations, factor V Leiden and prothrombin 20210A, both linked to thrombosis.

The researchers found that the overall risk of venous thrombosis was increased 7-fold in patients with a malignancy vs. persons without malignancy. Patients with hematological (related to blood) malignancies had a 28-fold increased risk of venous thrombosis, followed by those with lung cancer and gastrointestinal cancer. The risk of venous thrombosis was highest in the first few months after the diagnosis of malignancy (53 times greater risk). Patients with cancer with distant metastases had a higher risk vs. patients without distant metastases (20 times greater risk). Carriers of the factor V Leiden mutation who also had cancer had a 12-fold increased risk vs. individuals without cancer and factor V Leiden. Similar results were indirectly calculated for the prothrombin 20210A mutation in patients with cancer.

"Assuming a baseline risk of 1 to 4 patients with venous thrombosis per 1,000 per year, a 5 percent prevalence of factor V Leiden and a 2 percent prevalence of the prothrombin 20210A mutation, among 10,000 patients with cancer, we would expect 8 to 34 patients with venous thrombosis due to factor V Leiden or the prothrombin 20210A mutation. Screening for factor V Leiden and the prothrombin 20210A mutation and subsequent prophylactic anticoagulant therapy with an effectivity of 80 percent would prevent annually 7 to 27 venous thrombotic events per 10,000 patients with cancer screened (numbers needed to screen: 700-2,700), which does not make screening a useful strategy. Rather than screening for factor V Leiden or the prothrombin 20210A mutation, it may be more cost-effective to consider prophylactic anticoagulant therapy for patients with cancer who have an increased risk to develop venous thrombosis," the authors conclude.

(JAMA. 2005;293:715-722. Available post-embargo at JAMA.com)

Editor's Note: This research was supported by grants from the Netherlands Heart Foundation and from the Dutch Cancer Foundation.


Story Source:

The above story is based on materials provided by Urnal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Urnal Of The American Medical Association. "Patients With Cancer Have Highly Increased Risk For Blood Clots." ScienceDaily. ScienceDaily, 16 February 2005. <www.sciencedaily.com/releases/2005/02/050212184503.htm>.
Urnal Of The American Medical Association. (2005, February 16). Patients With Cancer Have Highly Increased Risk For Blood Clots. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2005/02/050212184503.htm
Urnal Of The American Medical Association. "Patients With Cancer Have Highly Increased Risk For Blood Clots." ScienceDaily. www.sciencedaily.com/releases/2005/02/050212184503.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins