Featured Research

from universities, journals, and other organizations

Sex Hormone Metabolite Reduces Stress, Anxiety In Female Rats

Date:
February 17, 2005
Source:
Emory University Health Sciences Center
Summary:
A steroid hormone released during the metabolism of progesterone, the female sex hormone, reduces the brain's response to stress, according to research in rats by scientists at Emory University School of Medicine, the Yerkes National Primate Research Center and Atlanta's Center for Behavioral Neuroscience.

ATLANTA -- A steroid hormone released during the metabolism of progesterone, the female sex hormone, reduces the brain's response to stress, according to research in rats by scientists at Emory University School of Medicine, the Yerkes National Primate Research Center and Atlanta's Center for Behavioral Neuroscience. The scientists found evidence that the progesterone metabolite allopregnanolone reduces the brain's response to corticotropin-releasing factor (CRF), a peptide hormone that plays an important role in the stress response in animals. The finding, which was reported in the Nov. 10, 2004 edition of the Journal of Neuroscience, could provide a new drug target for treating anxiety and depression in women.

In the study, Emory researchers Donna Toufexis, PhD, Michael Davis, PhD and Carrie Davis, BS, and Alexis Hammond, BS, of Spelman College, compared how female rats with different levels of the sex hormones, estrogen and progesterone, reacted to loud noises after injections of CRF into the brain's lateral ventricles. CRF injections usually increase the "acoustic startle response" in this test used to gauge stress and anxiety, a phenomenon called CRF-enhanced startle.

In the first experiment, the scientists compared acoustic startle responses after CRF injection in an estrogen-only group, an estrogen-plus-progesterone group and a control group that did not receive any sex hormones. All the rats lacked ovaries and the ability to produce sex hormones naturally. Acoustic startle response was unaffected in the estrogen-only group and the control group. In the estrogen-plus-progesterone group, however, CRF-enhanced startle was significantly lower than in the other groups.

In another set of experiments, the researchers discovered that lactating female rats with naturally high levels of progesterone had markedly lower CRF-enhanced startle responses compared to virgin females with intact ovaries. "Findings from theses initial experiments pointed toward the conclusion that progesterone inhibits the effect of CRF on the acoustic startle response," said Toufexis.

To test this hypothesis, the researchers gave only progesterone to female rats lacking ovaries, then compared the acoustic startle response to female rats without ovaries injected with corn oil. The progesterone group displayed significantly lower CRF-enhanced startle responses. When ovariectomized females were tested with allopregnanolone alone it also reduced CRF-enahnced startle.

In a final experiment, the scientists compared the effects on females that received progesterone with those that received medroxy-progesterone, an artificial progestin that binds to progesterone receptors but does not metabolize into the progesterone metabolite allopregnanolone. Only natural progesterone reduced CRF-enhanced startle.

Previous studies have determined that allopregnanolone enhances the activity of GABA, the main inhibitory neurotransmitter in the central nervous system, at its receptors throughout the brain. This mechanism, Toufexis said, likely accounts for progesterone's blunting effect on the brain's stress system.

Findings from the study correlate with clinical evidence that some people suffering from depression or anxiety have low allopregnanolone levels that normalize after treatment with anti-depressant medications.

"New drugs could potentially be developed that mimic the effect of allopregnanolone on the GABA receptor, providing a new approach for controlling mood disorders in women," said Toufexis. "The next step is to determine where exactly allopregnanolone is working in the brain to reduce the effect of CRF."

###

The research was supported by the Center for Behavioral Neuroscience through the National Science Foundation, by the National Institute of Mental Health, and by the Woodruff Foundation


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "Sex Hormone Metabolite Reduces Stress, Anxiety In Female Rats." ScienceDaily. ScienceDaily, 17 February 2005. <www.sciencedaily.com/releases/2005/02/050212190826.htm>.
Emory University Health Sciences Center. (2005, February 17). Sex Hormone Metabolite Reduces Stress, Anxiety In Female Rats. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2005/02/050212190826.htm
Emory University Health Sciences Center. "Sex Hormone Metabolite Reduces Stress, Anxiety In Female Rats." ScienceDaily. www.sciencedaily.com/releases/2005/02/050212190826.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins