Featured Research

from universities, journals, and other organizations

Study Documents Initial Differences In Sexual Transmission Of HIV Between Males And Females

Date:
March 3, 2005
Source:
Johns Hopkins Medical Institutions
Summary:
A genetic analysis of viral RNA from 10 heterosexual couples, in which one partner has sexually transmitted HIV to the other, provides the first documentation of some differences in how the virus infects males and females.

A genetic analysis of viral RNA from 10 heterosexual couples, in which one partner has sexually transmitted HIV to the other, provides the first documentation of some differences in how the virus infects males and females. According to the Hopkins researchers who led the study, this initial research is essential to understanding why these differences occur and for future development of a vaccine or other preventive methods that could stop sexual transmission of HIV-1.

The couples in the study come from the Rakai Cohort, a Uganda-based population in a long-term study of HIV infection. The researchers tested each couple's viral RNA to determine which variants, or kinds of HIV-1 strain, were present in each man and woman. Variants of HIV-1 can be distinguished by differences in the gene (gp160) for their protein envelope. The findings showed that only a subset of HIV-1 variants in the initially infected partner was transmitted to the newly infected partner, and the predominant variant in males was not the kind that infected their female partners. And, women infected by men had a greater number of variants than men infected by women.

The selection of HIV-1 during sexual transmission: differences in gp160 diversity in male-to-female versus female-to-male transmission. Oliver Laeyendecker, Jordyn Gamiel, James Shepard, Xianbin Li, David Serwadda, Nelson Sewankambo, Fred Wabwire-Mangen, Francine McCutchan, Jonathan Toma, Wei Huang, Ronald Gray, Maria Wawer, and Thomas Quinn.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Study Documents Initial Differences In Sexual Transmission Of HIV Between Males And Females." ScienceDaily. ScienceDaily, 3 March 2005. <www.sciencedaily.com/releases/2005/02/050228122946.htm>.
Johns Hopkins Medical Institutions. (2005, March 3). Study Documents Initial Differences In Sexual Transmission Of HIV Between Males And Females. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2005/02/050228122946.htm
Johns Hopkins Medical Institutions. "Study Documents Initial Differences In Sexual Transmission Of HIV Between Males And Females." ScienceDaily. www.sciencedaily.com/releases/2005/02/050228122946.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins