Featured Research

from universities, journals, and other organizations

Chemists Synthesize Molecule That Helps Body Battle Cancers, Malaria

Date:
March 18, 2005
Source:
University Of Illinois At Urbana-Champaign
Summary:
The first synthesis of QS-21A, a medicinally important molecule that helps the body battle disease, has been achieved by chemists at the University of Illinois at Urbana-Champaign.

David Y. Gin, a professor of chemistry, and his colleagues have synthesized QS-21A, a medically important molecule that helps the body battle disease.
Credit: Photo by Kwame Ross

CHAMPAIGN, Ill. — The first synthesis of QS-21A, a medicinally important molecule that helps the body battle disease, has been achieved by chemists at the University of Illinois at Urbana-Champaign.

Related Articles


In clinical trials, QS-21A has been shown to significantly improve the body’s immune response in vaccine therapies against aggressive diseases such as melanoma, breast cancer, small-cell lung cancer, prostate cancer, HIV-1 and malaria. An extract from the bark of the South American tree Quillaja saponaria Molina, QS-21A is available only in small quantities.

“Now that we have synthesized this remarkable molecule and confirmed its structure, we are in a position to examine how it works and investigate ways to improve its performance,” said David Y. Gin, a professor of chemistry at Illinois. Gin and his collaborators describe their work in a paper that has been accepted for publication in the Journal of the American Chemical Society, and posted on its Web site.

An extremely powerful adjuvant, QS-21A enhances the potency of antigens introduced in the body to elicit an immune response, allowing for lower vaccine doses with greater effectiveness. The molecule could therefore save patients money on expensive drugs and stretch limited supplies of antigens and vaccines.

Gin and his collaborators are now exploring ways to improve the molecule. By investigating structure activity relationships, they want to strip away nonessential structures, leaving a simpler and more potent core.

“One frequent problem encountered with vaccines is ensuring that the vaccine is potent enough to elicit a strong immune response,” Gin said. “We will continue looking for ways to produce new molecules similar to QS-21A that will enhance the body’s natural immune response to eradicate diseases.”

The research team included postdoctoral research associates Pengfei Wang, Mauricio Navarro-Villalobos and Bridget D. Rohde, and graduate student Yong-Jae Kim. The work was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "Chemists Synthesize Molecule That Helps Body Battle Cancers, Malaria." ScienceDaily. ScienceDaily, 18 March 2005. <www.sciencedaily.com/releases/2005/03/050308140214.htm>.
University Of Illinois At Urbana-Champaign. (2005, March 18). Chemists Synthesize Molecule That Helps Body Battle Cancers, Malaria. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2005/03/050308140214.htm
University Of Illinois At Urbana-Champaign. "Chemists Synthesize Molecule That Helps Body Battle Cancers, Malaria." ScienceDaily. www.sciencedaily.com/releases/2005/03/050308140214.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins