Featured Research

from universities, journals, and other organizations

UC Davis Researchers Discover New Link Between C-reactive Protein, And Heart Disease And Stroke

Date:
March 30, 2005
Source:
University Of California, Davis - Medical Center
Summary:
The cells that line the arteries are able to produce C-reactive protein, according to a study funded by the National Institutes of Health and published in the April issue of American Journal of Pathology.

SACRAMENTO, Calif. -- The cells that line the arteries are able to produce C-reactive protein, according to a study funded by the National Institutes of Health and published in the April issue of American Journal of Pathology.

C-reactive protein is a risk marker for heart disease and is known to be produced in the liver, but UC Davis School of Medicine researchers Ishwarlal Jialal and Sridevi Devaraj found that endothelial cells also produce C-reactive protein, a key finding that helps to explain how plaque formation is initiated. This is particularly important because endothelial cells are supposed to protect the arteries from C-reactive protein.

"This is an extremely important finding," says Jialal, professor of pathology and internal medicine and director of the Laboratory for Atherosclerosis and Metabolic Research at UC Davis Medical Center. "We have convincingly demonstrated in this paper that aortic and coronary artery endothelial cells produce and secrete C-reactive protein. We also showed within the artery, mature white cells, called macrophages, make chemical messengers, cytokines, which enhance the C-reactive protein secretion by endothelial cells at least 10-fold.

"This tells us that there is cross-talk in the active plaque where these cells act in concert to cause very high C-reactive protein levels in the atheroma, which is the accumulation of plaque on the innermost layer of the artery," Jialal said. "The C-reactive protein produced by endothelial cells can not only act on the endothelial cells, but also on macrophages and smooth muscle cells in the atheroma. This creates a vicious cycle, leading to plaque instability and rupture, and ultimately heart attacks and strokes."

Work at UC Davis and other institutions has shown that C-reactive protein induces endothelial cell dysfunction, thus promoting plaque formation. C-reactive protein causes endothelial cells to produce less nitric oxide and to increase the number of cell adhesion molecules. This, in turn, allows damaging leukocytes to enter the vessels. Devaraj and Jialal also showed that C-reactive protein induces endothelial cells to produce plasminogen activator inhibitor, or PAI-1, which promotes clot formation. In addition, recent studies suggest that plaque tissue also produces C-reactive protein.

Coronary heart disease is the nation's single leading cause of death. According to the American Heart Association, approximately 1.2 million Americans will have a coronary attack this year. Almost a half million of these people will die. About 7.1 million Americans have survived a heart attack. And another 6.4 million Americans have experienced chest pain or discomfort due to reduced blood supply to the heart.

The good news is that reducing the concentration of C-reactive protein with targeted drugs, such as statins, has been shown to reduce cardiovascular events. Treating other risk factors such as smoking, obesity, high blood pressure and high cholesterol are also shown to reduce the levels of C-reactive protein.

Senthil Kumar Venugopal, a postgraduate researcher in the Laboratory of Atherosclerosis and Metabolic Research participated in the study.


Story Source:

The above story is based on materials provided by University Of California, Davis - Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, Davis - Medical Center. "UC Davis Researchers Discover New Link Between C-reactive Protein, And Heart Disease And Stroke." ScienceDaily. ScienceDaily, 30 March 2005. <www.sciencedaily.com/releases/2005/03/050325151253.htm>.
University Of California, Davis - Medical Center. (2005, March 30). UC Davis Researchers Discover New Link Between C-reactive Protein, And Heart Disease And Stroke. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2005/03/050325151253.htm
University Of California, Davis - Medical Center. "UC Davis Researchers Discover New Link Between C-reactive Protein, And Heart Disease And Stroke." ScienceDaily. www.sciencedaily.com/releases/2005/03/050325151253.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins