Featured Research

from universities, journals, and other organizations

Cancer Research Could Lead To Improved Detection Methods

April 15, 2005
University of Liverpool
Research into the development of cancer at the University of Liverpool could lead to earlier and improved detection methods for the disease.

Related Articles

By applying this technology to early pre-cancerous lesions, they have made important discoveries on the timing of DNA damage and the response of cells to this damage.

Their research, funded by the Roy Castle Lung Cancer Foundation and published in this week's edition of Nature, demonstrates that breaks occur at fragile sites of cells' DNA very early in the carcinogenic process. The DNA breaks are produced by abnormalities in the cell division process that are caused carcinogens such as tobacco smoke.

This DNA damage occurs very early in the development of pre-cancerous cells and could highlight those at risk of developing cancer at a much earlier stage than current screening processes allow.

Dr Lakis Liloglou, Head of the University's Lung Cancer Molecular Biomarkers Group, explained: "These breaks occur preferentially in certain sites of the genome that are known to be fragile and induce a cell's pre-cancerous state. This initiates the cell's repair system, which fixes errors or leads damaged cells to die.

"If, however, the overall process fails because of an overload of an overload of carcinogens and the cell is not killed, this leads to multiplication of damaged cells which may develop in into a cancer. Identification of such damage could thus serve as a very early warning signal of cancer."

The team found that these mistakes (genomic instability at fragile sites) in the early stage of lung tumours and continuous exposure to carcinogens increase the chance that a precancerous lesion will progress to a cancerous one.

Dr Liloglou continued: "We have shown that early lesions that are virtually undetectable with current clinical methods carry molecular changes or mistakes that may commit cells to develop into a tumour."

"Our study emphasizes the need to develop molecular tests for detecting cancer at its pre-clinical stages, when chemoprevention regimes can be effective with minimal side effects for patients."

The study was carried out in collaboration with the Democritos National Centre of Scientific Research and the University of Athens Medical School in Greece, the Wistar Institute and the University of Pennsylvania in Philadelphia and the Mount Sinai School of Medicine in New York.

Professor John Field, Director of the Roy Castle Lung Cancer Research Programme at the University of Liverpool Cancer Research Centre, said: "This large international collaboration has identified one of the major mechanisms involved in the development of cancer, which will have enormous implications on our understanding of this devastating disease; in particular in lung cancer patients where early lesions are rarely identified prior to the diagnosis of the disease."

Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.

Cite This Page:

University of Liverpool. "Cancer Research Could Lead To Improved Detection Methods." ScienceDaily. ScienceDaily, 15 April 2005. <www.sciencedaily.com/releases/2005/04/050414145245.htm>.
University of Liverpool. (2005, April 15). Cancer Research Could Lead To Improved Detection Methods. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2005/04/050414145245.htm
University of Liverpool. "Cancer Research Could Lead To Improved Detection Methods." ScienceDaily. www.sciencedaily.com/releases/2005/04/050414145245.htm (accessed March 30, 2015).

Share This

More From ScienceDaily

More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations

Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.


Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News


Free Subscriptions

Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins