Featured Research

from universities, journals, and other organizations

New Insights Into Skin Blistering Disease Pop Up

Date:
May 31, 2005
Source:
Journal Of Clinical Investigation
Summary:
Pemphigus is a deadly skin blistering disease that occurs when patients' produce antibodies that attack proteins in their own cells -- called autoantibodies. In pemphigus, the body mounts abnormal attacks on molecules called desmogleins, which normally hold skin cells together. When autoantibodies attack desmogleins, the cells separate from each other, causing lesions and blisters that do not heal. The disease is fatal if not treated.

Pemphigus is a deadly skin blistering disease that occurs when patients' produce antibodies that attack proteins in their own cells -- called autoantibodies. In pemphigus, the body mounts abnormal attacks on molecules called desmogleins, which normally hold skin cells together. When autoantibodies attack desmogleins, the cells separate from each other, causing lesions and blisters that do not heal. The disease is fatal if not treated. Current therapy for this disease involves non-specific immune system suppression.

Related Articles


In a study appearing online on March 24, in advance of the April 1 print edition of the Journal of Clinical Investigation, Aimee Payne and colleagues from the University of Pennsylvania analyze the pathogenic antibodies to desmogleins in a patient with pemphigus in order to make progress into the development of more targeted therapy for this disease.

The authors engineered antibodies like those found in the pemphigus patient, then showed that the antibodies inactivate desmogleins and have harmful effects on skin cells in culture. When transferred to mice, the antibodies induced blisters like those seen in pemphigus patients. The researchers also identified the regions on the antibody that cause the autoimmune response.

This data is the first to report the successful cloning of human antibodies in pemphigus that reproduce the disease in vitro and in mice, and offer a new opportunity for the development of therapies to treat this deadly disease. These results add to our understanding of cell adhesion in general and the pathogenesis of pemphigus disease.

###

TITLE: Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display


Story Source:

The above story is based on materials provided by Journal Of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Clinical Investigation. "New Insights Into Skin Blistering Disease Pop Up." ScienceDaily. ScienceDaily, 31 May 2005. <www.sciencedaily.com/releases/2005/05/050528125531.htm>.
Journal Of Clinical Investigation. (2005, May 31). New Insights Into Skin Blistering Disease Pop Up. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2005/05/050528125531.htm
Journal Of Clinical Investigation. "New Insights Into Skin Blistering Disease Pop Up." ScienceDaily. www.sciencedaily.com/releases/2005/05/050528125531.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins