Featured Research

from universities, journals, and other organizations

Study Links Regions Of Two Chromosomes To Susceptibility For Type Of Autism

Date:
June 9, 2005
Source:
Cincinnati Children's Hospital Medical Center
Summary:
Cincinnati Children's Hospital Medical Center study links regions of two chromosomes to susceptibility for a type of autism characterized by regression in development.

CINCINNATI -- A new Cincinnati Children's Hospital Medical Center study links regions of two chromosomes to susceptibility for a type of autism characterized by regression in development. Developmental regression can include the loss of previously acquired language, social skills or both.

Moreover, the study is the first to identify involvement of chromosome 21 in this type of autism. This may explain the increased prevalence of autism spectrum disorders (ASD) among children with Down syndrome, who have an extra copy of chromosome 21 and are 10 times more likely to have an ASD than the general population.

The findings represent "the important first step in identifying genetic variants that may contribute to susceptibility to this specific type of ASD," says Cindy Molloy, M.D., lead author of the study. Dr. Molloy is a physician at Cincinnati Children's in the Center for Epidemiology and Biostatistics and in the division of developmental disabilities.

The study is published in the online edition of the journal Molecular Psychiatry.

Dr. Molloy and colleagues in the division of human genetics examined a national database and DNA bank of hundreds of families with ASD. They identified 32 pairs of siblings, one trio of siblings and one pair of cousins who showed definite evidence of regression at the age of approximately 18 to 24 months. They confirmed previous evidence for linkage with ASD on chromosome 7 and found new evidence for susceptibility on chromosome 21 in this subset of ASD families. The research team is now sequencing genes in those regions to find the specific genetic variant that either contributes to susceptibility or modifies the disease.

"Among children with autism or ASD, 20 to 30 percent have a history of regression," says Dr. Molloy. "We think this represents a genetically distinct subgroup."

The Autism Society of Greater Cincinnati has just awarded Dr. Molloy a $40,000 grant to continue this research and extend it to families in the Cincinnati area.

Autism is a complex developmental disability that affects an individual in the areas of social interaction and communication. Autism is a spectrum disorder that affects each individual differently and to varying degrees of severity. As many as 1.5 million Americans - children and adults - are thought to have autism today, according to the Autism Society of America.


Story Source:

The above story is based on materials provided by Cincinnati Children's Hospital Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cincinnati Children's Hospital Medical Center. "Study Links Regions Of Two Chromosomes To Susceptibility For Type Of Autism." ScienceDaily. ScienceDaily, 9 June 2005. <www.sciencedaily.com/releases/2005/06/050608052944.htm>.
Cincinnati Children's Hospital Medical Center. (2005, June 9). Study Links Regions Of Two Chromosomes To Susceptibility For Type Of Autism. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2005/06/050608052944.htm
Cincinnati Children's Hospital Medical Center. "Study Links Regions Of Two Chromosomes To Susceptibility For Type Of Autism." ScienceDaily. www.sciencedaily.com/releases/2005/06/050608052944.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins