Featured Research

from universities, journals, and other organizations

Bone Loss After Liver Transplants Can Be Prevented

Date:
August 18, 2005
Source:
John Wiley & Sons, Inc.
Summary:
The results of a new study published in the August 2005 issue of Liver Transplantation found that the drug used to treat osteoporosis, when used in combination with calcium and vitamin D, can prevent the additional bone loss that commonly occurs after liver transplants.

A new study found that the drug used to treat osteoporosis, when used in combination with calcium and vitamin D, can prevent the additional bone loss that commonly occurs after liver transplants. The treatment also helped stabilize bone loss in patients who already had osteoporosis, and helped improve their bone mineral density (BMD).

The results of this study appear in the August 2005 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/livertransplantion.

Osteoporosis occurs in a large number of patients with end stage liver disease, and is often worsened by the immunosuppressive drugs normally given to prevent rejection following liver transplants. To date, however, studies have not been conducted and no guidelines exist for the treatment of bone loss following liver transplant.

In order to determine the effectiveness of medication in preventing bone loss after liver transplants, researchers led by Gunda Millonig of the Department of Gastroenterology and Hepatology at Innsbruck Medical University in Innsbruck, Austria, assessed osteoporosis in 136 pre-liver transplant patients between January 1999 and December 2003. All patients on the waiting list were given 1000 mg of calcium and 400 IE of vitamin D daily, and bisphosphonate (alendronate, the drug used to treat osteoporosis) was given following liver transplant to those patients who had either osteopenia (a decrease in bone density that can lead to osteoporosis) or osteoporosis before transplant. Patients whose BMD decreased following the transplant were also given bisphosphonate.

"The striking result of this study was that alendronate combined with calcium and vitamin D almost completely prevented further bone loss in the first 4 months after LT [liver transplant]," the authors state. "This is a significant improvement compared to the natural course of bone loss within the first few months after LT as reported in numerous publications." In addition, patients with osteopenia and osteoporosis, which accounted for 72 percent of the patients in the study, remained stable on the alendronate therapy for the first four months after transplant and showed significantly improved BMD over the next three years, although for the most part their BMD did not ever reach normal levels.

"Our study suggests that oral alendronate therapy immediately after LT in patients with osteoporosis/osteopenia is effective in preventing bone loss subsequent to LT," the authors conclude. They note, however, that while the results are promising, further randomized studies are needed.

###

Article: "Alendronate in Combination with Calcium and Vitamin D Prevents Bone Loss After Orthotopic Liver Transplantation: A Prospective Single-Centre Study," Gunda Millonig, Ivo W. Graziadei, Dagmar Eichler, Karl-Peter Pfeiffer, Gerd Finkenstedt, Petra Muehllechner, Alfred Koenigsrainer, Raimund Margreiter, Wolfgang Vogel, Liver Transplantation; August 2005; Published Online: July 20, 2005. Article can be found online via Wiley InterScience at http://www.interscience.wiley.com/journal/livertransplantion.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Bone Loss After Liver Transplants Can Be Prevented." ScienceDaily. ScienceDaily, 18 August 2005. <www.sciencedaily.com/releases/2005/08/050814175027.htm>.
John Wiley & Sons, Inc.. (2005, August 18). Bone Loss After Liver Transplants Can Be Prevented. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2005/08/050814175027.htm
John Wiley & Sons, Inc.. "Bone Loss After Liver Transplants Can Be Prevented." ScienceDaily. www.sciencedaily.com/releases/2005/08/050814175027.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins