Featured Research

from universities, journals, and other organizations

Researchers Find Chemotherapy, Radiation Better For Patients With Locally Advanced Lung Cancer

Date:
September 2, 2005
Source:
Thomas Jefferson University
Summary:
While researchers have learned in the last decade that combining chemotherapy with radiation is better than radiation alone for treating non-small cell lung cancer patients with locally advanced disease – cancer confined to the lungs – finding the right combination of drugs – and the best timing of treatment – has been tricky. A new study led by lung cancer specialists at Jefferson Medical College adds to growing evidence that giving patients both chemotherapy and radiation in the beginning of treatment may help patients live longer.

While researchers have learned in the last decade thatcombining chemotherapy with radiation is better than radiation alonefor treating non-small cell lung cancer patients with locally advanceddisease – cancer confined to the lungs – finding the right combinationof drugs – and the best timing of treatment – has been tricky.

Anew study led by lung cancer specialists at Jefferson Medical Collegeadds to growing evidence that giving patients both chemotherapy andradiation in the beginning of treatment may help patients live longer.Non-small-cell lung cancer accounts for about 80 percent of all casesof lung cancer. An estimated 40,000 Americans are diagnosed each yearwith locally advanced disease.

“This is a further step in lookingat what is the best combination of two chemotherapy agents withradiation, which will enable us to move forward and study it moresystematically,” says Walter J. Curran Jr., M.D., professor and chairof radiation oncology at Jefferson Medical College at Thomas JeffersonUniversity in Philadelphia and clinical director of Jefferson’s KimmelCancer Center, who led the research.

“There are new biologicagents we want to test with chemotherapy, with radiation and withboth,” he notes. “Finding the best combination of chemotherapy andradiation provides a template by which we can test these agents.”

The results appear September 1, 2005 in the Journal of Clinical Oncology.

Inthe multicenter, randomized phase 2 trial, researchers compared threedifferent approaches to treating inoperable non-small-cell lung cancerthat had not spread beyond the lungs. They divided more than 250patients into three treatment arms. One group received chemotherapybefore radiation. A second group had chemotherapy before and duringradiation. Patients in the third arm received chemotherapy andradiation at the same time, then added a little more chemotherapyafter. Each arm had the same schedule of radiation and were given thesame two standard chemotherapy agents, carboplatin and paclitaxel.

Dr.Curran and his colleagues found that the patients in the third arm didbest, living several months more on average when compared against thestandard treatment.

“That’s in keeping with the observedresults of other studies,” Dr. Curran says. “Giving radiation andchemotherapy from day one appears to be the best approach for thesepatients,” though side effects can at first appear to be worse.

“Researchersare already looking at targeted agents such as bevacizumab, cetuximaband other agents with chemotherapy and radiation in lung cancer,” hesays. “This kind of study will help guide us as to which schedule touse.”

Some other institutions that participated in the trialinclude medical centers at the University of Pittsburgh and VanderbiltUniversity and Rush University Medical Center.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Researchers Find Chemotherapy, Radiation Better For Patients With Locally Advanced Lung Cancer." ScienceDaily. ScienceDaily, 2 September 2005. <www.sciencedaily.com/releases/2005/09/050902070740.htm>.
Thomas Jefferson University. (2005, September 2). Researchers Find Chemotherapy, Radiation Better For Patients With Locally Advanced Lung Cancer. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2005/09/050902070740.htm
Thomas Jefferson University. "Researchers Find Chemotherapy, Radiation Better For Patients With Locally Advanced Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/09/050902070740.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins