Featured Research

from universities, journals, and other organizations

Symptoms Of Depression May Worsen Heart Failure

Date:
September 8, 2005
Source:
Ohio State University
Summary:
New research suggests that depression may hasten the progression of heart disease by increasing the levels of a key protein that causes inflammation. In a study of 32 people with heart failure, the 14 patients who felt the most depressed had nearly twice the levels of this protein in their blood.

Related Articles


In a study of 32 peoplewith heart failure, the 14 patients who felt the most depressed hadnearly twice the levels of this protein in their blood.

Theprotein, tumor necrosis factor alpha (TNF-alpha), is one member of alarge family of proteins called cytokines, chemical messengers that aremobilized when the body is injured or has an infection. These cytokinesoften cause inflammation in their effort to repair an injured orinfected area of the body. In the case of heart failure, thisinflammation makes it even more difficult for the heart to pump blood.(Heart failure is a disease in which the heart loses the ability topump blood with normal efficiency.)

“People with heart failuretypically have much higher TNF-alpha levels than people without thedisease,” said Amy Ferketich, the study's lead author and an assistantprofessor of public health at Ohio State .

“But depression seems to make levels of this cytokine even higher, which is bad for patients.”

Thestudy's results appear in a recent issue of the American Heart Journal.Ferketich worked with Ohio State colleagues Jeanette PohorenceFerguson, a graduate student in pathology, and Philip Binkley, aprofessor of internal medicine.

They recruited 32 patients fromthe heart failure clinic at Ohio State . The participants answered the21-question Beck Depression Inventory, a tool that physicians andscientists use to measure symptoms of depression. Answers to eachquestion are given a value of zero (no symptoms at all) to 3 (severesymptoms). A score of 10 or more suggests that a patient has at leastmild symptoms of depression.

The researchers drew blood samplesfrom each patient. From these samples they evaluated levels of threecytokines: TNF-alpha, interleukin-6 (IL-6) and interleukin-1beta(IL-1beta). Previous research by other scientists has shown that thethree cytokines, which all cause inflammation, are elevated in patientswith heart failure.

Indeed, all of the patients in the study hadhigher-than-normal levels of each cytokine. However, TNF-alpha wasstill markedly higher in patients who reported feeling depressed on aregular basis.

“We were surprised to find that this wasn't thecase for the other two cytokines,” Ferketich said. “That suggests thatsomething about depression may trigger the production of TNF-alpha.”

Theresearchers measured cytokine levels in picograms, or trillionths of agram. Patients with scores of 10 or higher on the BDI had levels ofTNF-alpha nearly twice that of patients with a score less than 10 (4.9pg/ml vs. 2.7 pg/ml.)

Levels of the other two cytokines weresimilar for depressed and non-depressed patients: 5.9 pg/ml vs. 5.1pg/ml for IL-6 and 4.4 pg/ml and 3.6 pg/ml for IL-1beta, respectively.

Other researchers estimate that anywhere from 24 to 42 percent of heart failure patients also suffer from depression.

“Depressionclearly raises the levels of one cytokine, which plays a role inincreasing inflammation,” Ferketich said. “What we don't know for sureis if depression causes the inflammation which may lead to heartfailure or if heart failure causes depression which acceleratesinflammation.”

A study at Duke University found that patientswith major depression are twice as likely to die or to be re-admittedto the hospital a second time within 12 months.

“Patients withheart disease are prone to developing depression,” Ferketich said.“Physicians need to pay more attention to this. But research stillneeds to be done to find out if treating patients with anti-depressantswould help to actually slow the progression of heart disease.”

The study was supported by the National Institutes of Health's National Heart, Lung and Blood Institute.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Symptoms Of Depression May Worsen Heart Failure." ScienceDaily. ScienceDaily, 8 September 2005. <www.sciencedaily.com/releases/2005/09/050908082829.htm>.
Ohio State University. (2005, September 8). Symptoms Of Depression May Worsen Heart Failure. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2005/09/050908082829.htm
Ohio State University. "Symptoms Of Depression May Worsen Heart Failure." ScienceDaily. www.sciencedaily.com/releases/2005/09/050908082829.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins