Featured Research

from universities, journals, and other organizations

Key To Stem Cell Transplant Success Is Tricking Immune System

Date:
September 11, 2005
Source:
Imperial College London
Summary:
Tricking the bodys immune system into ignoring stem cells will be the key to successful stem cell transplants, according to Professor Maggie Dallman, Imperial College London, speaking at the BA Festival of Science. Professor Dallman is investigating how to trick the body into producing regulatory cells, which prevent the bodys immune system from attacking its own molecules, at the site of a stem cell transplant.

Tricking the body's immune system into ignoring stem cells will be the key to successful stem cell transplants, according to Professor Maggie Dallman, Imperial College London, speaking at the BA Festival of Science.

Professor Dallman is investigating how to trick the body into producing regulatory cells, which prevent the body's immune system from attacking its own molecules, at the site of a stem cell transplant. If they were present when stem cells were introduced into the body, the regulatory cells would inhibit the body's natural response to 'foreign' cells, meaning the stem cells would be accepted.

Drug therapies can prevent traditional organ grafts from being destroyed in the short term but organ transplants typically fail after a number of years as the body's immune system rejects the new tissue. Scientists are hopeful that harnessing regulatory cells would prevent stem cell transplants from facing similar rejection.

Professor Dallman, from Imperials department of Cell and Molecular Biology, explains: "Stem cell transplants will offer fantastic possibilities for helping people with any disease where there is tissue damage or degeneration. It is vital to work out how to prevent these transplants from being rejected.

"We know from over 50 years of experience with transplants that a major issue affecting the success of such procedures is the immune systems rejection of grafted tissue. Our recent experiments suggest that we could use regulatory cells to stop the immune system responding to foreign transplants, whilst leaving the rest of the immune system intact", she adds.

Cloning stem cells using a patient's own cells is another option for preventing the rejection of stem cell transplants. This would have a low risk of rejection because cloned cells would contain the patients own DNA. However, the cost and intricate nature of this procedure means that it may not prove to be a practical option for widespread use, according to Professor Dallman.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Key To Stem Cell Transplant Success Is Tricking Immune System." ScienceDaily. ScienceDaily, 11 September 2005. <www.sciencedaily.com/releases/2005/09/050910090618.htm>.
Imperial College London. (2005, September 11). Key To Stem Cell Transplant Success Is Tricking Immune System. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2005/09/050910090618.htm
Imperial College London. "Key To Stem Cell Transplant Success Is Tricking Immune System." ScienceDaily. www.sciencedaily.com/releases/2005/09/050910090618.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins