Featured Research

from universities, journals, and other organizations

Scientists Block Viruses From Entering Cells

Date:
September 12, 2005
Source:
University of California - Los Angeles
Summary:
First identified more than 20 years ago at UCLA, defensins are peptides naturally produced by the immune system to ward off viruses. However, it was unclear how defensins worked. Now UCLA and NIH scientists have discovered that a specific defensin called retrocyclin-2 (RC2) binds to carbohydrate-containing proteins in cell membranes.

First identified more than 20 years ago at UCLA, defensins arepeptides naturally produced by the immune system to ward off viruses.However, it was unclear how defensins worked. Now UCLA and NIHscientists have discovered that a specific defensin calledretrocyclin-2 (RC2) binds to carbohydrate-containing proteins in cellmembranes. This mechanism erects molecular barricades that blockattacking viruses from entering and infecting the cell. RC2 stops thevirus in its tracks, preventing it from replicating and spreadingthroughout the body.

The NIH/UCLA team used human and animal cell lines todemonstrate RC2's protection against the influenza virus. The team'searlier studies suggest that RC2 offers great promise as the leadcompound for new antiviral drugs to fight off HIV and herpes, as well.Unlike antibodies, however, defensins are not pathogen specific. Inaddition to blocking viruses, RC2 also kills several bacteria that arehighly resistant to conventional antibiotics.

Authors of the study include Dr. Robert Lehrer, DistinguishedProfessor of Medicine at the David Geffen School of Medicine at UCLA,and Leonid Chernomordik, Ph.D., section chief of Membrane Biology,Laboratory of Cellular and Molecular Biophysics, who led the NIH team.

###

FUNDING: The National Institute of Child Health and HumanDevelopment and NIH's Intramural Research Program supported theresearch. The W.M. Keck Foundation established the UCLA FunctionalProteomics Center, which also participated in the study.

JOURNAL: The Sept. 11 online edition of Nature Immunology publishes the research. A PDF of the manuscript is available upon request.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "Scientists Block Viruses From Entering Cells." ScienceDaily. ScienceDaily, 12 September 2005. <www.sciencedaily.com/releases/2005/09/050912075142.htm>.
University of California - Los Angeles. (2005, September 12). Scientists Block Viruses From Entering Cells. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2005/09/050912075142.htm
University of California - Los Angeles. "Scientists Block Viruses From Entering Cells." ScienceDaily. www.sciencedaily.com/releases/2005/09/050912075142.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins