Featured Research

from universities, journals, and other organizations

University College London Study Shows Beans Beat Cancer

Date:
September 15, 2005
Source:
University College London
Summary:
Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound - inositol pentakisphosphate - found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. The findings, published in the latest issue of Cancer Research, suggest that a diet enriched in such foods could help prevent cancer, while the inhibitor offers a new tool for anti-cancer therapy.

Scientists have discovered a new and potent anti-cancer compound ineveryday food. The collaborative study led by UCL (University CollegeLondon) shows that the compound - inositol pentakisphosphate - found inbeans, nuts and cereals inhibits a key enzyme (phosphoinositide3-kinase) involved in tumour growth. The findings, published in thelatest issue of Cancer Research, suggest that a diet enriched in suchfoods could help prevent cancer, while the inhibitor offers a new toolfor anti-cancer therapy.

Related Articles


Phosphoinositide 3-kinase is a key player in the development andprogression of human tumours. Scientists have been exploringphosphoinositide 3-kinase as a target for cancer treatment butinhibitors have been difficult to develop because of problems with thechemical stability and toxicity of the inhibiting substances. Now, ateam of scientists led by Dr Marco Falasca of the UCL Sackler Institutehave discovered that a natural compound, inositol pentakisphosphate,inhibits the activity of the enzyme, suggesting it could be used todevelop new treatments for cancer.

In the study, the compound was tested in mouse models and oncancer cells. Not only was it found to inhibit the growth of tumours inmice, but the phosphate also enhanced the effect of cytotoxic drugs inovarian and lung cancer cells. The findings suggest that inositolpentakisphosphate could be used to sensitize cancer cells to the actionof commonly used anti-cancer drugs.

Inositol pentakisphosphate is a non-toxic, water-solublecompound found in most legumes (such as lentils, peas and beans) and inwheat bran and nuts. These properties make the compound a promisingtherapeutic agent since conventional chemotherapy agents can be toxicto different degrees, whereas in the study, the inositol phosphateagent was found to be non-toxic even at higher concentrations.

Dr Marco Falasca of the UCL Sackler Institute says: "Our studysuggests the importance of a diet enriched in food such as beans, nutsand cereals which could help prevent cancer. Our work will now focus onestablishing whether the phosphate inhibitor can be developed into ananti-cancer agent for human therapy. We believe that inositolpentakisphosphate is a promising anti-cancer tool and we hope to bringit to clinical testing soon."


Story Source:

The above story is based on materials provided by University College London. Note: Materials may be edited for content and length.


Cite This Page:

University College London. "University College London Study Shows Beans Beat Cancer." ScienceDaily. ScienceDaily, 15 September 2005. <www.sciencedaily.com/releases/2005/09/050915002836.htm>.
University College London. (2005, September 15). University College London Study Shows Beans Beat Cancer. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2005/09/050915002836.htm
University College London. "University College London Study Shows Beans Beat Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/09/050915002836.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins