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Tissue Stiffness Drives Tumor Formation

Date:
September 27, 2005
Source:
University of Pennsylvania School of Medicine
Summary:
Researchers at the University of Pennsylvania School of Medicine have shown that tumor formation is generated by a complex interaction of both mechanical as well as chemical signals, and the resulting tissue stiffening induces molecular signals that promote the cancerous behavior of cells. Force, growth, and tumor behavior are inextricably linked and this enhanced understanding of the necessary fusion of these factors may lead to the development of new tumor therapies or targets.

Extracellular matrix stiffness influences tissue growth and changes in function by modulating cell contractility. For example, as stiffness increases in connective tissue, the cells of a normal breast duct (panel 1) start to behave aberrantly, causing the structure of the duct to degrade (panel 2), as the uncontrolled cell growth of duct-lining cells invade the duct tube (panel 3).
Credit: Matthew Naszek, University of Pennsylvania School of Medicine and Cell Press


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The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


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University of Pennsylvania School of Medicine. "Tissue Stiffness Drives Tumor Formation." ScienceDaily. ScienceDaily, 27 September 2005. <www.sciencedaily.com/releases/2005/09/050926082535.htm>.
University of Pennsylvania School of Medicine. (2005, September 27). Tissue Stiffness Drives Tumor Formation. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2005/09/050926082535.htm
University of Pennsylvania School of Medicine. "Tissue Stiffness Drives Tumor Formation." ScienceDaily. www.sciencedaily.com/releases/2005/09/050926082535.htm (accessed April 18, 2014).

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