Featured Research

from universities, journals, and other organizations

Hopkins Geneticist Discovers Mutations In Cancer Cells That Suggest New Forms Of Treatment

Date:
September 29, 2005
Source:
Johns Hopkins Medical Institutions
Summary:
Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors, a discovery that could pave the way for more effective cancer treatments. The Hopkins team, in conjunction with researchers at the J. Craig Venter Institute in Rockville, Md., discovered DNA abnormalities in two tyrosine kinase proteins already known to disrupt normal cell activity and contribute to tumor formation.

Researchers at Johns Hopkins have identified three new geneticmutations in brain tumors, a discovery that could pave the way for moreeffective cancer treatments.

Related Articles


The Hopkins team, in conjunction with researchers at the J. CraigVenter Institute in Rockville, Md., discovered DNA abnormalities in twotyrosine kinase proteins already known to disrupt normal cell activityand contribute to tumor formation.

The discovery of these mutations is especially significant, theresearchers say, because tyrosine kinases can be targeted usingpharmaceuticals.

"We picked these proteins to sequence because receptor tyrosinekinases sit on the cell surface where anticancer drugs can get atthem," said Gregory J. Riggins, M.D., co-lead author of the study andan associate professor in the Department of Neurosurgery at The JohnsHopkins University School of Medicine.

In the study, published in the October 4th edition of TheProceedings of the National Academy of Sciences, the researchersidentified two of the previously unknown mutations in fibroblast growthreceptor 1 (FGFR1) and one in platelet derived growth factor receptoralpha (PDGFRA).

FGFR1 and PDGFRA, said Riggins, have been implicated in severalother cancers such as colorectal, breast and ovarian cancer, as well aschronic myelogenous leukemia, gastrointestinal stromal tumors andlymphoma.

Riggins and colleagues analyzed a catalog of 518 protein kinasesequences taken from the Human Genome Project. Using high-throughputgene sequencing equipment based at the Venter Institute's JointTechnology Center, they resequenced 20 targeted proteins from tissuesamples of brain tumor cells from Hopkins. The cells came from 19glioblastoma tumors from eight females and 11 males ranging in age from7 to 77 years. Glioblastomas are malignant tumors of the centralnervous system usually found in the cortex of the brain.

Researchers discovered the mutations after comparing theresequenced genes with corresponding genes from the human genomesequence.

A previous study by Hopkins researchers, led by VictorVelculescu, M.D., Ph.D., used high-throughput gene sequencing toidentify 14 mutated genes that have potential links to the growth ofcolon cancer cells, according to Riggins. These discoveries suggestpotential future therapies that might use small molecules andantibodies to regulate the function of the mutated genes.

The success of that study prompted researchers to take thesame approach to search for new drug targets for glioblastoma, a braintumor for which current therapies are weak.

According the Riggins, the recent advances in genomicinformation and technology have set the stage for the assembling of acomplete catalog of molecular alterations that contribute to cancers.Genes involved in the tyrosine kinase family will be important in thesefuture studies because they play a significant role in signalingbetween cancer cells and what's around them. Combined with theremarkable clinical success doctors have had with the moleculartargeting of this family of genes, Riggins said, these new findingscould result in effective new treatments for cancer.

"The next step," he added, "is to find inhibitors of thesemutations and find out how we can reverse the effects of thesemutations in the cancer cell. Our hope is that we can target enough ofthese mutations to treat the cancer."


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Hopkins Geneticist Discovers Mutations In Cancer Cells That Suggest New Forms Of Treatment." ScienceDaily. ScienceDaily, 29 September 2005. <www.sciencedaily.com/releases/2005/09/050928234900.htm>.
Johns Hopkins Medical Institutions. (2005, September 29). Hopkins Geneticist Discovers Mutations In Cancer Cells That Suggest New Forms Of Treatment. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2005/09/050928234900.htm
Johns Hopkins Medical Institutions. "Hopkins Geneticist Discovers Mutations In Cancer Cells That Suggest New Forms Of Treatment." ScienceDaily. www.sciencedaily.com/releases/2005/09/050928234900.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins