Featured Research

from universities, journals, and other organizations

Study Demonstrates How Gene Variant May Contribute To Cancer Development

Date:
October 5, 2005
Source:
JAMA and Archives Journals
Summary:
A relatively common cancer susceptibility gene appears to be frequently acquired in metastatic lesions from colorectal cancer, and give cancer cells a growth advantage, according to a study in the October 5 issue of JAMA.

A relatively common cancer susceptibility gene appears to be frequentlyacquired in metastatic lesions from colorectal cancer, and give cancercells a growth advantage, according to a study in the October 5 issueof JAMA.

Transforming growth factor beta (TGF-beta) is a potent naturallyoccurring inhibitor of cell growth, according to background informationin the article. It exerts its action by binding to type I (TGFBR1) andtype II (TGFBR2) receptors located on the cell membrane. Increased cellgrowth due to decreased TGF-beta growth inhibition may contribute tocancer development. TGFBR1*6A is a common polymorphism (variation) ofTGFBR1. Previous studies have shown that TGFBR1*6A is one of the firstcandidate tumor susceptibility alleles (DNA codings of the same gene)that is found in a large proportion of the general population (13.7percent) and significantly increases cancer risk by approximately 24percent. How TGFBR1*6A contributes to cancer development is largelyunknown.

Boris Pasche, M.D., Ph.D., of Northwestern University Feinberg Schoolof Medicine, Chicago, and colleagues conducted a study that included531 patients with a diagnosis of head and neck cancer, colorectalcancer, or breast cancer recruited from 3 centers in the United Statesand from 1 center in Spain from June 1, 1994, through June 30, 2004.Multiple genetic testing of the cancer cells was conducted.

The researchers found that TGFBR1 mutated into TGFBR1*6A, i.e. wassomatically acquired, in 13 of 44 (29.5 percent) colorectal cancermetastases, in 4 of 157 (2.5 percent) of colorectal tumors, in 4 of 226(1.8 percent) head and neck primary tumors, and in none of the 104patients with breast cancer.

While TGF-beta inhibits the growth of normal cells, cancer cellssecrete larger amounts of TGF-beta than their normal counterparts. Theresearchers showed that, in the presence of TGF-beta, the growth ofcancer cells that carry the TGFBR1*6A gene is 55 percent greater thancancer cells that do not carry this gene, indicating that TGFBR1*6Agive cancer cells a selective advantage. This, together with thefindings that TGFBR1*6A is acquired by tumors, may explain why half ofall liver metastases from colorectal cancer carried the TGFBR1*6A genewhile it is only found in 14 percent of the general population.

"... individuals who carry the *6A allele, either in thegermline or somatically acquired by the tumor, may have a greaterlikelihood of developing metastases than individuals who do not carrythis allele. *6A may therefore serve as a useful biomarker in cancer."The authors add that TGFBR1*6A may bestow cancer cells with a growthadvantage in the presence of TGF-beta.

"Since 13.7 percent of the general population and 17.1 percent ofpatients with a diagnosis of cancer carry at least 1 copy of the *6Aallele, our findings may have substantial public health importance. Thehigh frequency of *6A carriers in the general population and themoderately increased risk of breast, colon, and ovarian cancer that itconfers implies that the dominant effects of *6A have an incompletepenetrance. Additional studies are needed to determine whichenvironmental and genetic factors may modify the penetrance of *6A inthese tumor types," the researchers write.

"The results highlight a new facet of TGF-beta signaling in cancer andsuggest that TGFBR1*6A may represent a potential therapeutic target incancer."



Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Study Demonstrates How Gene Variant May Contribute To Cancer Development." ScienceDaily. ScienceDaily, 5 October 2005. <www.sciencedaily.com/releases/2005/10/051005080819.htm>.
JAMA and Archives Journals. (2005, October 5). Study Demonstrates How Gene Variant May Contribute To Cancer Development. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2005/10/051005080819.htm
JAMA and Archives Journals. "Study Demonstrates How Gene Variant May Contribute To Cancer Development." ScienceDaily. www.sciencedaily.com/releases/2005/10/051005080819.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins