Featured Research

from universities, journals, and other organizations

Study Demonstrates How Gene Variant May Contribute To Cancer Development

Date:
October 5, 2005
Source:
JAMA and Archives Journals
Summary:
A relatively common cancer susceptibility gene appears to be frequently acquired in metastatic lesions from colorectal cancer, and give cancer cells a growth advantage, according to a study in the October 5 issue of JAMA.

A relatively common cancer susceptibility gene appears to be frequentlyacquired in metastatic lesions from colorectal cancer, and give cancercells a growth advantage, according to a study in the October 5 issueof JAMA.

Related Articles


Transforming growth factor beta (TGF-beta) is a potent naturallyoccurring inhibitor of cell growth, according to background informationin the article. It exerts its action by binding to type I (TGFBR1) andtype II (TGFBR2) receptors located on the cell membrane. Increased cellgrowth due to decreased TGF-beta growth inhibition may contribute tocancer development. TGFBR1*6A is a common polymorphism (variation) ofTGFBR1. Previous studies have shown that TGFBR1*6A is one of the firstcandidate tumor susceptibility alleles (DNA codings of the same gene)that is found in a large proportion of the general population (13.7percent) and significantly increases cancer risk by approximately 24percent. How TGFBR1*6A contributes to cancer development is largelyunknown.

Boris Pasche, M.D., Ph.D., of Northwestern University Feinberg Schoolof Medicine, Chicago, and colleagues conducted a study that included531 patients with a diagnosis of head and neck cancer, colorectalcancer, or breast cancer recruited from 3 centers in the United Statesand from 1 center in Spain from June 1, 1994, through June 30, 2004.Multiple genetic testing of the cancer cells was conducted.

The researchers found that TGFBR1 mutated into TGFBR1*6A, i.e. wassomatically acquired, in 13 of 44 (29.5 percent) colorectal cancermetastases, in 4 of 157 (2.5 percent) of colorectal tumors, in 4 of 226(1.8 percent) head and neck primary tumors, and in none of the 104patients with breast cancer.

While TGF-beta inhibits the growth of normal cells, cancer cellssecrete larger amounts of TGF-beta than their normal counterparts. Theresearchers showed that, in the presence of TGF-beta, the growth ofcancer cells that carry the TGFBR1*6A gene is 55 percent greater thancancer cells that do not carry this gene, indicating that TGFBR1*6Agive cancer cells a selective advantage. This, together with thefindings that TGFBR1*6A is acquired by tumors, may explain why half ofall liver metastases from colorectal cancer carried the TGFBR1*6A genewhile it is only found in 14 percent of the general population.

"... individuals who carry the *6A allele, either in thegermline or somatically acquired by the tumor, may have a greaterlikelihood of developing metastases than individuals who do not carrythis allele. *6A may therefore serve as a useful biomarker in cancer."The authors add that TGFBR1*6A may bestow cancer cells with a growthadvantage in the presence of TGF-beta.

"Since 13.7 percent of the general population and 17.1 percent ofpatients with a diagnosis of cancer carry at least 1 copy of the *6Aallele, our findings may have substantial public health importance. Thehigh frequency of *6A carriers in the general population and themoderately increased risk of breast, colon, and ovarian cancer that itconfers implies that the dominant effects of *6A have an incompletepenetrance. Additional studies are needed to determine whichenvironmental and genetic factors may modify the penetrance of *6A inthese tumor types," the researchers write.

"The results highlight a new facet of TGF-beta signaling in cancer andsuggest that TGFBR1*6A may represent a potential therapeutic target incancer."



Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Study Demonstrates How Gene Variant May Contribute To Cancer Development." ScienceDaily. ScienceDaily, 5 October 2005. <www.sciencedaily.com/releases/2005/10/051005080819.htm>.
JAMA and Archives Journals. (2005, October 5). Study Demonstrates How Gene Variant May Contribute To Cancer Development. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2005/10/051005080819.htm
JAMA and Archives Journals. "Study Demonstrates How Gene Variant May Contribute To Cancer Development." ScienceDaily. www.sciencedaily.com/releases/2005/10/051005080819.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins