Featured Research

from universities, journals, and other organizations

Hair-raising Stem Cells Identified: Swiss Study Shows That Hair Follicles Contain Bonafide Multipotent Stem Cells

Date:
October 6, 2005
Source:
Ecole Polytechnique Fédérale de Lausanne
Summary:
A research team led by Yann Barrandon at the EPFL (Ecole Polytechnique Federale de Lausanne) and the Lausanne University Hospital has discovered that the hair follicle contains true multipotent stem cells, capable of developing into the many different cell types needed for hair growth and follicle replacement. In an article appearing Oct 4 in the Proceedings of the National Academy of Sciences, they demonstrate that these holoclones can be used for long-term follicle renewal.

Related Articles


In 2001, Barrandon was part of aFrench research team who reported in the scientific journal Cell thatstem cells could be used to generate skin containing hair and sebaceousglands in mice. But at that time it was unclear whether the stem cellsin hair follicles were true stem cells, capable of long-term renewal,or multipotent progenitor cells that would not permanently engraft inthe follicle.

In the current PNAS study, the Swiss researchershave answered that question, using rat whisker hair follicles todemonstrate that the clonogenic keratinocytes in hair follicles aretrue stem cells.

Barrandon's group isolated stem cells from ratwhisker follicles, labelled them, and grew them in culture for 140generations. They then implanted progeny cells into the skin of newbornmice whose hair follicles were just being formed. This skin was thengrafted onto athymic (nude) mice. Some cells were incorporated intodeveloping follicles, but other follicles were completely made up oflabelled cells. Each progeny cell contributed to the formation of eightdifferent types of cell in the follicle, including those of the outerroot sheath, inner root sheath, the hair shaft, the sebaceous gland andthe epidermis.

After 125 days, a biopsy was taken from the graft,and labelled stem cells were isolated, subcloned, cultivated and thenonce again transplanted. The rat whisker stem cells participated againin forming all the cell types needed to form the hair follicle andsebaceous glands, resulting in hair bulbs that underwent repeatednormal phases of growth, rest and regeneration. The fact that thetransplanted cells participate in the hair cycle over long periods oftime shows that they are true multipotent stem cells and notprogeniture cells.

"With the progeny of a single stem cell, itwould be theoretically possible to generate the complete hair bulb of ahuman being, and one that would last for years," explains Barrandon.

Theability of the stem cells in hair follicles to repeatedly regenerateall the different cell types of the follicle and sebaceous glands hasimportant implications for regenerative medicine. The method could oneday be used to regenerate hair on patients with severe burns. Thisstudy is a logical complement to other work in Barrandon's Laboratoryof Stem Cell Dynamics, recognized for research into the reconstructionof injured tissues and organs.


Story Source:

The above story is based on materials provided by Ecole Polytechnique Fédérale de Lausanne. Note: Materials may be edited for content and length.


Cite This Page:

Ecole Polytechnique Fédérale de Lausanne. "Hair-raising Stem Cells Identified: Swiss Study Shows That Hair Follicles Contain Bonafide Multipotent Stem Cells." ScienceDaily. ScienceDaily, 6 October 2005. <www.sciencedaily.com/releases/2005/10/051006084613.htm>.
Ecole Polytechnique Fédérale de Lausanne. (2005, October 6). Hair-raising Stem Cells Identified: Swiss Study Shows That Hair Follicles Contain Bonafide Multipotent Stem Cells. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2005/10/051006084613.htm
Ecole Polytechnique Fédérale de Lausanne. "Hair-raising Stem Cells Identified: Swiss Study Shows That Hair Follicles Contain Bonafide Multipotent Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2005/10/051006084613.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins