Featured Research

from universities, journals, and other organizations

Researchers Show Beneficial Role Of Risk Calculator In Fighting Progression Of Glaucoma

Date:
October 19, 2005
Source:
University of California - San Diego
Summary:
A new glaucoma risk calculator, which estimates a patient's risk of converting from high eye pressure, or ocular hypertension, to glaucoma, will help physicians determine whether to initiate therapy for patients. High eye pressure is the leading risk factor for glaucoma, and is the only modifiable one. If glaucoma is untreated, vision loss may continue, leading to blindness in some individuals.

A new glaucoma risk calculator, which estimates a patient's risk of converting from high eye pressure, or ocular hypertension, to glaucoma, will help physicians determine whether to initiate therapy for patients. High eye pressure is the leading risk factor for glaucoma, and is the only modifiable one. If glaucoma is untreated, vision loss may continue, leading to blindness in some individuals.

"The risk assessment idea came to me after studying the cardiovascular model which measures cholesterol to determine whether or not to initiate a statin for cholesterol lowering by assessing cholesterol, age, blood pressure, and other risk factors," said Robert N. Weinreb, M.D., Director of the Hamilton Glaucoma Center at University of California, San Diego and Distinguished Professor of Ophthalmology at the UCSD School of Medicine, and co-developer of the calculator. "The glaucoma risk calculator is a tool which allows doctors to better assess patient risk levels and, if needed, recommend treatment options that can help decrease the progression of glaucoma in patients with ocular hypertension."

The risk calculator model will be reported at the American Academy of Ophthalmology annual meeting October 17 in Chicago, Ill., by Weinreb and Felipe A. Medeiros, M.D., Assistant Professor of Ophthalmology, at the UCSD Hamilton Glaucoma Center, lead author of the study demonstrating the risk calculator's effectiveness.

Glaucoma, one of the leading causes of blindness, is an eye disease in which damage to the optic nerve located in the back of the eye results in loss of eyesight. About half of patients with glaucoma have ocular hypertension. Treatment depends on the degree or stage of the glaucoma. Physicians might not prescribe any treatment for ocular hypertension, for example, when increased pressure in the eye is minimal and no nerve damage is present. Routine monitoring of the patient's peripheral vision and of the appearance of the optic nerve may be sufficient.

The glaucoma risk calculator is based on data collected from the multi-center National Eye Institute-sponsored Ocular Hypertension Treatment Study, which identified key patient risk factors (older age, high intraocular pressure, thinner central corneal thickness, larger vertical cup/disc ratio measurements and higher pattern standard deviation) predictive of disease progression from ocular hypertension to glaucoma. Although the OHT study results have provided a better understanding of the risk factors involved in the progression from ocular hypertension to glaucoma, physicians still face the challenge of combining these factors to assess individual patients.

Drs. Weinreb and Medeiros have taken these key factors and examined them in an independent population of 126 untreated patients studied at the Hamilton Glaucoma Center. The Scoring Tool for Assessing Risk (STAR) a five-year glaucoma risk assessment tool determines an individual patient's overall risk of developing glaucoma. Physicians assess the six key risk factors and position their findings at various points on the tool, which can help them determine the risk of conversion from ocular hypertension to glaucoma within the next five years.

"A collective assessment of these risk factors helps physicians identify those patients with elevated eye pressure who are more likely to progress to glaucoma and may benefit from early treatment," said Medeiros.

By identifying patients with a higher chance of developing damage, the risk calculator can help physicians make decisions leading to more rational treatment of patients at highest risk, as well as discontinuing treatment and monitoring of patients at lowest risk. This could result in greater consistency in treatment, improving quality of care for patients with ocular hypertension and a decrease in patients who go on to develop glaucoma.

###

The risk calculator research was supported by an independent research grant from Pfizer, Inc. The risk calculator research was validated in an independent population--as part of a study by the National Eye Institute sponsored by Diagnostic Innovations in Glaucoma Study.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University of California - San Diego. "Researchers Show Beneficial Role Of Risk Calculator In Fighting Progression Of Glaucoma." ScienceDaily. ScienceDaily, 19 October 2005. <www.sciencedaily.com/releases/2005/10/051019002110.htm>.
University of California - San Diego. (2005, October 19). Researchers Show Beneficial Role Of Risk Calculator In Fighting Progression Of Glaucoma. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/10/051019002110.htm
University of California - San Diego. "Researchers Show Beneficial Role Of Risk Calculator In Fighting Progression Of Glaucoma." ScienceDaily. www.sciencedaily.com/releases/2005/10/051019002110.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins