Featured Research

from universities, journals, and other organizations

Breath Test Offers Hope For Early Detection Of Lung-bacteria Growth In Cystic Fibrosis

Date:
October 19, 2005
Source:
University of California - Irvine
Summary:
Breath-analysis testing may prove to be an effective, non-invasive method for detecting the damaging lung-bacteria growth seen in cystic fibrosis, which would allow for early stage treatments that can extend the health of people with this disease, UC Irvine researchers have found.

Breath-analysis testing may prove to be an effective, non-invasive method for detecting the damaging lung-bacteria growth seen in cystic fibrosis, which would allow for early stage treatments that can extend the health of people with this disease, UC Irvine researchers have found.

Related Articles


By using a chemical analysis method developed for air-pollution testing, UCI chemists and pediatricians have found that people with cystic fibrosis exhale higher concentrations of sulfur compounds from their lungs than do people who don't have the disease.

These sulfur compounds, called sulfides, are known to be produced by bacteria, and lung disease in cystic fibrosis is accompanied by bacterial infections that cause chronic damage. The researchers found that the worse the pulmonary function in the cystic fibrosis patient, the higher the sulfide concentration in the breath sample, suggesting an increased amount of bacterial growth in the lungs.

"Early detection and antibiotic therapy has been promoted as a means to delay chronic bacterial lung growth and prolong life, and breath analysis may be an effective first step toward treatment," said Dr. Dan Cooper, a pediatric pulmonologist at UCI Medical Center, who led the study with F. Sherwood Rowland, the Donald Bren Research Professor of Chemistry, and fellow chemistry professor Donald Blake. "In the long term, these findings on sulfide levels also might help uncover some of the underlying mechanisms of the disease."

Study results appear this week in the early online version of the Proceedings of the National Academy of Sciences.

Cystic fibrosis is a genetic disease marked by an abnormally thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections. Although many lung bacteria are prevalent with the disease, in teens and adults, the Pseudomonas aeruginosa bacteria appears as the most prevalent cystic fibrosis pathogen and is strongly associated with respiratory deterioration and mortality. Over time, the bacteria transforms into treatment-resistant variants, and early detection is seen as key for aggressive antibiotic treatments to delay its growth.

In the study, graduate student Michael Kambourse, working with Blake and Rowland, examined exhaled breath from people with and without cystic fibrosis using laboratory methods developed for their atmospheric chemistry work. In that work, they measure the levels of trace gases in excess of the parts-per-billion range that contribute to local and regional air pollution. Their research group is one of the few in the world recognized for its ability to measure accurately at such small amounts.

In analyzing the breath samples, the researchers monitored levels of three sulfides in the cystic fibrosis patients -- carbonyl sulfide, dimethylsulfide and carbon disulfide. Significantly, they found that cystic fibrosis patients exhaled carbonyl sulfide (OCS) at rates up to 2˝ times higher than people who don't have the disease, making it an attractive target for future breath analysis.

The study determined that the regular air the test subjects breathed in had about 600 parts-per-trillion volume (pptv) of OCS. The non-cystic fibrosis subjects exhaled a mean average of 350 pptv of OCS, meaning that about 250 pptv of OCS was removed from the inhaled air. The cystic fibrosis subjects exhaled a mean average 490 pptv of OCS, and the three individuals with the weakest pulmonary function exhaled as much as 800 pptv, producing an excess of OCS. This suggests a substantial OCS source, probably bacterial, exists in their lungs, in addition to poorer processing of inhaled gas.

The researchers are continuing their breath-analysis work in areas of autism, diabetes and oral glucose tolerance testing. Most relevant are ongoing studies in which they are testing the profile of gases produced by bacteria, like P. aeruginosa.

"The ultra-trace gas breath analysis techniques used in this study not only show potential for cystic fibrosis treatment but possess wide-ranging clinical possibilities," Blake said.

The National Institutes of Health, the Cystic Fibrosis Foundation and the Joan Irvine Smith and Athalie R. Clarke Foundation supported the study.

###

About Cystic Fibrosis: Cystic fibrosis is a genetic disease affecting approximately 30,000 children and adults in the United States. A defective gene causes the body to produce an abnormally thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections. These thick secretions also obstruct the pancreas, preventing digestive enzymes from reaching the intestines to help break down and absorb food. The mucus also can block the bile duct in the liver, eventually causing permanent liver damage in approximately six percent of people with the disease. Because of improvements in antibiotics, exercise and diet, people with cystic fibrosis on average live into their 30s. (Source: Cystic Fibrosis Foundation)


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "Breath Test Offers Hope For Early Detection Of Lung-bacteria Growth In Cystic Fibrosis." ScienceDaily. ScienceDaily, 19 October 2005. <www.sciencedaily.com/releases/2005/10/051019002726.htm>.
University of California - Irvine. (2005, October 19). Breath Test Offers Hope For Early Detection Of Lung-bacteria Growth In Cystic Fibrosis. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2005/10/051019002726.htm
University of California - Irvine. "Breath Test Offers Hope For Early Detection Of Lung-bacteria Growth In Cystic Fibrosis." ScienceDaily. www.sciencedaily.com/releases/2005/10/051019002726.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins