Featured Research

from universities, journals, and other organizations

Scientists Use Stem Cells To Grow Cartilage

Date:
November 16, 2005
Source:
Imperial College London
Summary:
Scientists from Imperial College London have successfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation. Research to be published in Tissue Engineering shows how the Imperial team directed embryonic stem cells to become cartilage cells. This could allow doctors to grow cartilage for transplantation for a number of injuries and medical problems, including sports injuries, new cartilage for people having hip replacements, and even for cosmetic surgery.

Cartilage.
Credit: Image courtesy of Imperial College London

Scientists from Imperial College London have successfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation.

Cartilage is the dense connective tissue usually found between bones to allow the smooth movement of joints.

Research to be published in Tissue Engineering shows how the Imperial team directed embryonic stem cells to become cartilage cells. This could allow doctors to grow cartilage for transplantation for a number of injuries and medical problems, including sports injuries, new cartilage for people having hip replacements, and even for cosmetic surgery.

Dr Archana Vats, from Imperial College London and first author of the paper, said: "The ability to grow cartilage using stem cells could have enormous implications for a number of medical problems. With the UK's increasing ageing population there will be an inevitable increase in problems created by people living longer. Although doctors have been able to carry out joint replacements for a number of years, it has not possible to replace the worn out cartilage. By replacing the cartilage it may be possible to avoid the need for a joint replacement for some time."

The research involved growing human embryonic stem cells with chondrocytes or cartilage cells, in Petri dishes in the laboratory in a specialised system that encouraged them to change into cartilage cells. When this was compared with just growing the human embryonic stem cells alone, the mixed stem cells and cartilage were found to have higher levels of collagen, the protein constituent of cartilage.

The cells were then implanted in mice on a bioactive scaffold for 35 days. When they removed the scaffold, the cells were found to have formed new cartilage, showing they can be successfully transplanted in living tissue.

The scientists also believe this technique could be used in cosmetic and reconstructive surgery. When removing head and neck cancers, surgeons often have to cut away parts of cartilage, and then take grafts from other parts of the body. With this new technique doctors would potentially be able to take stem cells from the patient, grow them in a laboratory, and then transplant them after the surgery.

This work builds on an earlier collaboration between medical researchers and engineers at Imperial College. The team had previously developed the bioactive scaffold which was used as a scaffold to grow the stem cells on.

Dr Anne Bishop, from Imperial College London, and one of the authors, added: "The potential of stem cells has been widely known for many years, but it is only recently we have started to make progress towards the ultimate goal of using them in patients. These results show it may be as little as five years before this advance can be used to directly benefit patients for a huge variety of illnesses and injuries."

The team included Professor Dame Julia Polak, Head of the Tissue Engineering and Regenerative Medicine Centre, Imperial College London, as well as Mr Neil Tolley, ENT Dept, St Mary's Hospital and also researchers from the University of Bristol.

###

The work was funded by the St Mary's Paddington Charitable Foundation, The March of Dimes, the Medical Research Council and The Mason Medical Research Foundation.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Scientists Use Stem Cells To Grow Cartilage." ScienceDaily. ScienceDaily, 16 November 2005. <www.sciencedaily.com/releases/2005/11/051116174850.htm>.
Imperial College London. (2005, November 16). Scientists Use Stem Cells To Grow Cartilage. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2005/11/051116174850.htm
Imperial College London. "Scientists Use Stem Cells To Grow Cartilage." ScienceDaily. www.sciencedaily.com/releases/2005/11/051116174850.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins