Featured Research

from universities, journals, and other organizations

Drug May Fight Lupus And Atherosclerosis Simultaneously

Date:
November 21, 2005
Source:
Wake Forest University Baptist Medical Center
Summary:
People with lupus are prone to premature accelerated atherosclerosis. Now scientists at Wake Forest University School of Medicine think they have a way to prevent or decrease this atherosclerosis and prevent heart attacks.

People with lupus are prone to premature accelerated atherosclerosis. Now scientists at Wake Forest University School of Medicine think they have a way to prevent or decrease this atherosclerosis and prevent heart attacks.

"Premature accelerated atherosclerosis is one of the leading causes of death and disability in lupus," said Nilamadhab Mishra, M.D., a rheumatologist at Wake Forest University Baptist Medical Center. Using a drug called Trichostatin A (TSA) "may prevent or decrease premature atherosclerosis in lupus."

Mishra presented his findings today (Nov. 16) at the American College of Rheumatology meeting in San Diego.

The findings represent a merger of two lines of Mishra's animal research using TSA -- one showing that the drug reduced lupus symptoms, especially inflammation of the kidneys and enlarged spleens, and the other showing that TSA was effective against atherosclerosis.

Mishra was joined in the atherosclerosis research by several leading scientists in the Medical School's long-standing atherosclerosis research program.

Their research uses a mouse that was created to be prone to atherosclerosis when fed a diet high in cholesterol and with 10 percent of calories from palm oil, one of the more dangerous dietary vegetable fats since it is high in saturated fat.

Among the atherosclerosis researchers were John S. Parks, Ph.D., professor of comparative medicine, and Richard St. Clair, Ph.D., professor of pathology and head of the Section on Comparative Medicine.

For 12 weeks, the researchers fed a high-fat, high-cholesterol diet to two groups of the atherosclerosis-prone mice. One group got injections of TSA from the time they went on the diet, while the other group got no TSA. The TSA-treated group had markedly less atherosclerosis in key arteries, such as the aorta -- the body's main blood vessel -- and what plaque there was contained less cholesterol.

Scientists increasingly are viewing the depositing of cholesterol in the walls of arteries as an inflammatory reaction that attracts the disease-fighting macrophages, a type of white blood cell, which then become incorporated with cholesterol deposits to become plaque. The mice that had the TSA injections had a reduction in the gathering of macrophages.

Mishra said that TSA may be beneficial because it prevents certain genes from expressing proteins that are known to be involved in both lupus and atherosclerosis.

Mishra had reported earlier that TSA showed promise in treating lupus in a different, lupus-prone mouse model. The research raises the hope, said Mishra, that "lupus and atherosclerosis can be treated simultaneously."



Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Drug May Fight Lupus And Atherosclerosis Simultaneously." ScienceDaily. ScienceDaily, 21 November 2005. <www.sciencedaily.com/releases/2005/11/051121103337.htm>.
Wake Forest University Baptist Medical Center. (2005, November 21). Drug May Fight Lupus And Atherosclerosis Simultaneously. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2005/11/051121103337.htm
Wake Forest University Baptist Medical Center. "Drug May Fight Lupus And Atherosclerosis Simultaneously." ScienceDaily. www.sciencedaily.com/releases/2005/11/051121103337.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins