Featured Research

from universities, journals, and other organizations

Rutgers Researchers Create Tiny Chemical Cages To Enclose Drug, Pesticide Molecules

Date:
January 25, 2006
Source:
Rutgers, the State University of New Jersey
Summary:
Tiny chemical cages created by Rutgers researchers show potential for delivering drugs to organs or tissues where they're needed and making pesticides less hazardous to handle. These cage-like molecules measure a mere 3.2 nanometers wide. Researchers have shown a way to securely link component molecules together in a cage using an efficient, one-step process.

A stick representation of a nanocontainer molecule.
Credit: Image courtesy of Ralf Warmuth

Tiny chemical cages created by researchers at Rutgers, The State University of New Jersey, show potential for delivering drugs to organs or tissues where they’re needed without causing harm elsewhere.

These cage-like molecules, called nanocontainers or nanoscale capsules because they measure a mere 3.2 nanometers (billionths of a meter) wide, also could make pesticides less hazardous to handle, filter toxic substances out of wastewater and regulate the pace of reactions in chemical production.

“While the concept of chemical cages is not new, we’ve created new components and advanced the assembly process to increase the chance that they’ll become practical,” said Ralf Warmuth, associate professor of chemistry and chemical biology at Rutgers and lead researcher. “We’ve shown a way to securely link molecules together in a cage using an efficient, one-step process.”

In an article slated for an upcoming issue of the chemistry journal Angewandte Chemie International Edition, now available on the journal’s Web site at www3.interscience.wiley.com/cgi-bin/fulltext/112223539/PDFSTART, Warmuth and colleagues describe how they’ve used common organic chemicals and straightforward techniques to create nanocontainers. These octahedral (eight-sided) capsules, with their cavity volume of almost two cubic nanometers, could enclose one or more molecules of a medicine, pesticide or intermediate in a chemical manufacturing process that, if left uncaged, might prematurely decay or interact with other substances in passing.

Previous techniques for assembling molecular cages involved tradeoffs. With one approach, the synthesis technique was straightforward, but the pieces of the molecular cages were not bound as tightly to each other. Another approach resulted in tighter bonds, but the process required several carefully orchestrated steps. The Rutgers advance is a one-step process that creates tight chemical bonds, surpassing earlier approaches in simplicity and efficiency.

The Rutgers process involves combining six larger bowl-shaped molecules with 12 smaller linear molecules, or bridges, that link the bowls together, insides facing each other. Atoms at four sites along each bowl’s rim bond to atoms on the ends of the bridges. The atomic structure and properties of these molecules ensure that they naturally assemble themselves into capsules and do so with high yield when combined in proper proportions. Early research suggests that the connections between the bridges and bowls can be broken and reattached under controlled conditions to introduce “payload” molecules – such as a drug or pesticide – into the cage and extract them when needed.

The Rutgers team consisted of Warmuth, chemistry graduate students Xuejun Liu and Yong Liu, and undergraduate student Gina Li. The work was funded by grants from the National Science Foundation.


Story Source:

The above story is based on materials provided by Rutgers, the State University of New Jersey. Note: Materials may be edited for content and length.


Cite This Page:

Rutgers, the State University of New Jersey. "Rutgers Researchers Create Tiny Chemical Cages To Enclose Drug, Pesticide Molecules." ScienceDaily. ScienceDaily, 25 January 2006. <www.sciencedaily.com/releases/2006/01/060124223607.htm>.
Rutgers, the State University of New Jersey. (2006, January 25). Rutgers Researchers Create Tiny Chemical Cages To Enclose Drug, Pesticide Molecules. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2006/01/060124223607.htm
Rutgers, the State University of New Jersey. "Rutgers Researchers Create Tiny Chemical Cages To Enclose Drug, Pesticide Molecules." ScienceDaily. www.sciencedaily.com/releases/2006/01/060124223607.htm (accessed August 29, 2014).

Share This




More Matter & Energy News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Australian Airlines Relax Phone Ban Too

Australian Airlines Relax Phone Ban Too

Reuters - Business Video Online (Aug. 26, 2014) Qantas and Virgin say passengers can use their smartphones and tablets throughout flights after a regulator relaxed a ban on electronic devices during take-off and landing. As Hayley Platt reports the move comes as the two domestic rivals are expected to post annual net losses later this week. Video provided by Reuters
Powered by NewsLook.com
Hurricane Marie Brings Big Waves to California Coast

Hurricane Marie Brings Big Waves to California Coast

Reuters - US Online Video (Aug. 26, 2014) Huge waves generated by Hurricane Marie hit the Southern California coast. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Chinese Researchers Might Be Creating Supersonic Submarine

Chinese Researchers Might Be Creating Supersonic Submarine

Newsy (Aug. 26, 2014) Chinese researchers have expanded on Cold War-era tech and are closer to building a submarine that could reach the speed of sound. Video provided by Newsy
Powered by NewsLook.com
Breakingviews: India Coal Strained by Supreme Court Ruling

Breakingviews: India Coal Strained by Supreme Court Ruling

Reuters - Business Video Online (Aug. 26, 2014) An acute coal shortage is likely to be aggravated as India's supreme court declared government coal allocations illegal, says Breakingviews' Peter Thal Larsen. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins